Results 171 to 180 of about 39,703 (285)

Increased ATP production and P‐glycoprotein activity underlie the marked changes in blood–brain barrier transport of drugs in a mouse model of amyotrophic lateral sclerosis

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Patients with amyotrophic lateral sclerosis (ALS) are prescribed many medications for symptomatic relief. However, how potential alterations to the blood–brain barrier (BBB) affect the brain exposure of drugs in ALS remains under‐investigated. Experimental approach We used high‐dimensional proteomic analysis, cellular metabolism,
Yijun Pan   +10 more
wiley   +1 more source

Super‐Enhancer Target Gene CBP/p300‐Interacting Transactivator With Glu/Asp‐Rich C‐Terminal Domain, 2 Cooperates With Transcription Factor Forkhead Box J3 to Inhibit Pulmonary Vascular Remodeling

open access: yesCell Proliferation, EarlyView.
During hypoxia, the transcriptional effect of super‐enhancer in promoting CBP/p300‐interacting transactivator with Glu/Asp‐rich C‐terminal domain, 2 reduced, eventually leading to the thickening of the smooth muscle layer of the pulmonary artery.
Songyue Li   +11 more
wiley   +1 more source

Comparative cardiovascular risk of sulfonylureas with low‐ and high‐affinities for cardiac mitochondrial adenosine triphosphate‐sensitive potassium channels versus dipeptidyl peptidase‐4 inhibitors in patients with type 2 diabetes: A cohort study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To individually evaluate the cardiovascular safety of low‐ and high‐affinity cardiac mitochondrial ATP‐sensitive potassium (mitoKATP) channel sulfonylureas by comparing each to dipeptidyl peptidase‐4 inhibitors (DPP‐4i), a generally cardiovascular‐neutral comparator, given prior evidence suggesting greater cardiovascular risk with high ...
Mei‐Hsiu Chen   +8 more
wiley   +1 more source

Four kits for plasma digoxin radioimmunoassay compared. [PDF]

open access: bronze, 1979
Björn Bergdahl   +5 more
openalex   +1 more source

Intrinsic Influences on Medical Emergency Team Call Stand‐Down Decision‐Making: An Observational Study

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim The aim of this research was to describe factors that influence Intensive Care Unit liaison nurses' decision to stand down a medical emergency team call response. The decision to end a medical emergency team response for a deteriorating patient is referred to as the medical emergency team call stand‐down decision.
Natalie A. Kondos   +3 more
wiley   +1 more source

Digoxin [PDF]

open access: yes, 2018
C. Vidal, W.-R. Külpmann
openaire   +1 more source

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