Evaluation of digoxin dosing and therapeutic drug monitoring in adult patients receiving continuous venovenous hemodiafiltration [PDF]
Therapeutic Advances in Drug SafetyBackground Digoxin dosing guidance during continuous renal replacement therapy (CRRT) is scarce, relying on two case reports with pharmacokinetic modeling not subsequently validated by TDM and expert opinion.
Madison P. Nordin PharmD, MBA +3 more
doaj +2 more sources
Digoxin toxicity with therapeutic serum digoxin concentrations
Toxicology ReportsIntroduction: Digoxin is a cardiac glycoside used for rate control in atrial fibrillation and heart failure. Despite its efficacy, digoxin has a narrow therapeutic window and can cause severe side effects, including life-threatening arrhythmias ...
J. Graafsma +5 more
doaj +4 more sources
Yellow Oleander ( Thevetia peruviana) Toxicity from a Misrepresented Dietary Supplement: A Case Report [PDF]
Clinical Practice and Cases in Emergency MedicineIntroduction: The “lucky nut” is the seed of the yellow oleander plant, often sold as a medicinal supplement in unregulated markets and known to contain cardiac glycosides, which may cause life-threatening bradycardias and Digoxin-like toxicity upon ...
Samantha E. Long +3 more
doaj +2 more sources
Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug-Drug Interactions for Orforglipron, a Small Molecule Glucagon-Like Peptide-1 Receptor Agonist. [PDF]
Clin Pharmacol TherOrforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Morse BL +7 more
europepmc +2 more sources
Interaction between Chinese medicine and digoxin: Clinical and research update
Frontiers in Pharmacology, 2023 Background: Digoxin is one of the most widely and commonly used cardiac drug, which plays an irreplaceable role in treating heart failure and arrhythmia.
Wei Zhuang +6 more
doaj +1 more source
A 5 years assessment of patients with acute digoxin poisoning: A toxicoepidemiology study in Iran
Heart Views, 2021 Background: Digoxin poisoning leads to the development of cardiac and noncardiac complications. Digoxin immune fab is a safe and effective antidote, but clinical trials have not been performed in this regard, and most of the evidence is based on ...
Mitra Rahimi +3 more
doaj +1 more source
‘Digoxin conundrum – Time for validation?’
Indian Heart Journal, 2021 Despite no incontrovertible data, Digoxin use has been demonised. As a consequence, a lot of patients, stable on Digoxin, have been taken off it and offered alternative drugs.
O.P. Yadava
doaj +1 more source
Bioavailability of Digoxin and Beta-Methyl-Digoxin
Journal of International Medical Research, 1976 In a randomized crossover study the bioavailability of a single dose of digoxin and of beta-methyl-digoxin tablets was tested in four normal volunteers. No difference was found between the two products in the rate and extent of drug absorption using 6 day cumulative urinary excretion and serial serum concentration measurements.
L, Padeletti +3 more
openaire +2 more sources
Digoxin and Amiodarone on the Risk of Ischemic Stroke in Atrial Fibrillation: An Observational Study
Frontiers in Pharmacology, 2018 Purpose: The present study compared the risk of ischemic stroke in atrial fibrillation (AF) patients receiving digoxin and amiodarone.Methods: A retrospective cohort study was conducted using the longitudinal population-based database of Taiwan’s ...
Kuan-Cheng Lai +13 more
doaj +1 more source
The effect of digoxin on renal function in patients with heart failure
BMC Nephrology, 2021 Introduction Digoxin is used in patients with chronic heart failure (CHF) who remain symptomatic despite optimal medical treatment. Impaired renal function is commonly associated with CHF.
Parin Shah +5 more
doaj +1 more source