International Journal of Medical Toxicology and Forensic Medicine, 2021 Background: Digoxin is extensively prescribed for cardiac diseases, so its chronic or acute toxicity commonly occur. Although digoxin specific antibodies (anti-digoxin Fab) are recommended to be used in patients with cardiac ...
Farzad Gheshlagh +7 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2023 The current recommendations for monitoring digoxin, a narrow therapeutic index drug, are limited to confirming medication use or investigating suspicion of toxicity and fail our oath to do no harm.
Sridhar Rao Gona +5 more
doaj +1 more source
The cardiac work-loop technique:An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles [PDF]
, 2020 The cardiac work-loop technique closely mimics the intrinsic in vivo movement and characteristics of cardiac muscle function. In this study, six known inotropes were profiled using the work-loop technique to evaluate the potential of this method to ...
AJ Taberner +56 more
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Interaction between Chinese medicine and digoxin: Clinical and research update
Frontiers in Pharmacology, 2023 Background: Digoxin is one of the most widely and commonly used cardiac drug, which plays an irreplaceable role in treating heart failure and arrhythmia.
Wei Zhuang +6 more
doaj +1 more source
Clinical signs and symptoms of toxic serum digoxin levels in neonates
The Turkish Journal of Pediatrics, 2019 Digoxin is widely used in the treatment of congestive heart failure and some arrhythmias. Digoxin toxicity may occur easily because digoxin has a narrow therapeutic index.
Mehmet Mutlu +4 more
doaj +1 more source
The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat [PDF]
, 2010 The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d, p.o.) on digoxin pharmacokinetics and intestinal transport has been assessed.
Anna-Lena Ungell +12 more
core +2 more sources
Labeless and reversible immunosensor assay based upon an electrochemical current-transient protocol [PDF]
, 2003 A novel labeless and reversible immunoassay based upon an electrochemical current-transient protocol is reported which offers many advantages in comparison to classical immuno-biochemical analyses in terms of simplicity, speed of response, reusability
Davis, Frank +5 more
core +1 more source
A 5 years assessment of patients with acute digoxin poisoning: A toxicoepidemiology study in Iran
Heart Views, 2021 Background: Digoxin poisoning leads to the development of cardiac and noncardiac complications. Digoxin immune fab is a safe and effective antidote, but clinical trials have not been performed in this regard, and most of the evidence is based on ...
Mitra Rahimi +3 more
doaj +1 more source
Characterisation of the Na, K pump current in atrial cells from patients with and without chronic atrial fibrillation [PDF]
, 2003 <b>Objective:</b> To assess the contribution of the Na, K pump current (<i>I</i><sub>p</sub>) to the action potential duration (APD) and effective refractory period (ERP) in human atrial cells, and to investigate ...
Kane, K.A., Rankin, A.C., Workman, A.J.
core +1 more source
Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma [PDF]
, 2015 PURPOSE:To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment.METHODS:A panel of two ...
Abramson, David +13 more
core +2 more sources