Results 11 to 20 of about 39,814 (206)
Tissue digoxin concentrations and digoxin effect during the quinidine-digoxin interaction
Journal of the American College of Cardiology, 1985 Quinidine elevates serum digoxin concentration in part by reducing the volume of distribution of digoxin, which implies that quinidine displaces digoxin from tissues. The purposes of this study were to: 1) measure the effect of quinidine on tissue digoxin concentrations, and 2) determine if quinidine alters the relation between myocardial digoxin ...
Warner, Natalie J. +2 more
openaire +3 more sources
Digoxin toxicity with therapeutic serum digoxin concentrations [PDF]
Toxicology ReportsDigoxin is a cardiac glycoside used for rate control in atrial fibrillation and heart failure. Despite its efficacy, digoxin has a narrow therapeutic window and can cause severe side effects, including life-threatening arrhythmias. Literature and guidelines on management of digoxin toxicity remain inconsistent whether to include serum digoxin ...
Graafsma, J. +5 more
openaire +5 more sources
, 2022 Digoxin is a cardiac glycoside used in the treatment of heart failure and arrhythmia. It has a positive effect on ventricular contraction. However, it causes a decrease in heart rate due to its negative effect on the atrioventricular (AV) node.
Küçük, Uğur +3 more
core +1 more source
Bioavailability of Digoxin and Beta-Methyl-Digoxin
Journal of International Medical Research, 1976 In a randomized crossover study the bioavailability of a single dose of digoxin and of beta-methyl-digoxin tablets was tested in four normal volunteers. No difference was found between the two products in the rate and extent of drug absorption using 6 day cumulative urinary excretion and serial serum concentration measurements.
L, Padeletti +3 more
openaire +2 more sources
Digoxin is a potent inhibitor of Bunyamwera virus infection in cell culture
, 2023 Drug repurposing is a valuable source of new antivirals because many compounds used to treat a variety of pathologies can also inhibit viral infections.
Pacheco González, Beatriz +10 more
core +1 more source
Clinical experience with titrating doses of digoxin antibodies in acute digoxin poisoning. (ATOM-6)
, 2021 For acute digoxin poisoning, it has been recommended to give bolus doses of 10–20 vials or potentially larger than needed doses calculated from dose ingested or the measured concentration. However, a recent revision of internal Poisons Information Centre
Geoffrey K. Isbister (8281572) +4 more
core +1 more source
Characterisation of the Na, K pump current in atrial cells from patients with and without chronic atrial fibrillation [PDF]
, 2003 <b>Objective:</b> To assess the contribution of the Na, K pump current (<i>I</i><sub>p</sub>) to the action potential duration (APD) and effective refractory period (ERP) in human atrial cells, and to investigate ...
Kane, K.A. +5 more
core +1 more source
Advanced Science, EarlyView.By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang +13 more
wiley +1 more source
Advanced Science, EarlyView.Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen +8 more
wiley +1 more source