Results 21 to 30 of about 36,624 (198)

Recognize and Treatment of Digitalis Intoxication

Majalah Kardiologi Indonesia, 2013
Background: Digitalis is the oldest compound in cardiovascular medicine that continues to be used in contemporary clinical practice. It is one of the most frequently prescribed medications and has historically been implicated as one of the most common ...
Dewi H Suprobo, Bambang B Siswanto, Yoga Yuniadi, Ganesja M Harimurti   +3 more
doaj   +1 more source

Digoxin and Heart Failure: Are We Clear Yet?

Cardiovascular Innovations and Applications, 2017
The Digoxin Investigation Group trial has multiple flaws in the trial design for the findings to be universally applicable. Digoxin in low serum concentrations (0.5–0.9 ng/mL) has been shown to decrease mortality in heart failure patients.
Amit Gupta, Melissa Dakkak, Alan Miller
doaj   +1 more source

Tissue digoxin concentrations and digoxin effect during the quinidine-digoxin interaction

Journal of the American College of Cardiology, 1985
Quinidine elevates serum digoxin concentration in part by reducing the volume of distribution of digoxin, which implies that quinidine displaces digoxin from tissues. The purposes of this study were to: 1) measure the effect of quinidine on tissue digoxin concentrations, and 2) determine if quinidine alters the relation between myocardial digoxin ...
Warner, Natalie J., Thomas Barnard, J., Thomas Bigger, J.   +2 more
openaire   +2 more sources

The effect of different digoxin concentrations on heart tissue and antioxidant status in iron-overloaded rats

ARYA Atherosclerosis, 2018
BACKGROUND: Thalassaemia is a hereditary disorder and has an economic burden on patients and the government. The most prevalent complication in these patients is iron overload which is followed by cardiomyopathy.
Beydolah Shahouzehi, Hamid Reza Nasri, Yaser Masoumi-Ardakani   +2 more
doaj   +1 more source

Digoxin Suppresses Tumor Malignancy through Inhibiting Multiple Src-Related Signaling Pathways in Non-Small Cell Lung Cancer. [PDF]

PLoS ONE, 2015
Non-small cell lung cancer is the predominant type of lung cancer, resulting in high mortality worldwide. Digoxin, a cardiac glycoside, has recently been suggested to be a novel chemotherapeutic agent.
Sheng-Yi Lin, Hsiu-Hui Chang, Yi-Hua Lai, Ching-Hsiung Lin, Min-Hsuan Chen, Gee-Chen Chang, Meng-Feng Tsai, Jeremy J W Chen   +7 more
doaj   +1 more source

THE EFFECT OF ENDOTOXEMIA ON THE PHARMACOKINETICS OF DIGOXIN IN CONSCIOUS MALE RABBITS

Zagazig Journal of Pharmaceutical Sciences, 2002
Multiple organ failure (MOF) is induced by Escherichia coli lipopolysaccharide (LPS) alters the clearance of several drugs in experimental animals and human being.
Atef El-Gharbawy
doaj   +1 more source

Treatment with Digoxin – is it a clinical challenge? A Retrospective Analysis of Hospitalizations due to Digoxin intoxication

Journal of Education, Health and Sport
Introduction and purpose: Digoxin, a cardiac glycoside derived from Digitalis lanata, has stood as a cornerstone in the treatment of various cardiovascular disorders for centuries.
Marcin Wais, Marlena Zając, Dariusz Gruca, Paweł Zalewski, Wiktor Wróblewski, Adam Raabe, Michał Tchórz   +6 more
doaj   +1 more source

Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

BMC Medicine, 2004
Background The ABC transporter P-glycoprotein (P-gp) is recognized as a site for drug-drug interactions and provides a mechanistic explanation for clinically relevant pharmacokinetic interactions with digoxin.
Michaëlsson Karl, Artursson Per, Hallberg Pär, Englund Gunilla, Melhus Håkan   +4 more
doaj   +1 more source

The effect of calcium in water hardness on digoxin plasma levels in an experimental rat model [PDF]

ARYA Atherosclerosis, 2020
BACKGROUND: Digoxin is a drug for ventricular rate control in atrial fibrillation (AF). The major challenge in digoxin therapy is to adjust the appropriate concentration range for this drug due to its narrow therapeutic index.
Shabnam Shahsavand, Mohammad Moshirfar, Seyed Hassan Seyed-Sharifi, Mohammad Amin Younessi-Heravi, Reza Ghasemi, Morteza Valaei, Mohsen Yaghubi   +6 more
doaj   +1 more source

Charting the Future of Stereoselective Carbohydrate Synthesis: The Essential Role of Cross‐Disciplinary Innovation

Advanced Science, EarlyView.
Cross‐disciplinary endeavors are blossoming across the broad chemical sciences. This perspective provides a glimpse into the rewarding interdisciplinary journey taken by the Charles Loh research group in pioneering the σ‐hole based catalytic glycosylation strategy.
Charles C. J. Loh
wiley   +1 more source