Results 21 to 30 of about 35,085 (202)

Recognize and Treatment of Digitalis Intoxication

Majalah Kardiologi Indonesia, 2013
Background: Digitalis is the oldest compound in cardiovascular medicine that continues to be used in contemporary clinical practice. It is one of the most frequently prescribed medications and has historically been implicated as one of the most common ...
Dewi H Suprobo, Bambang B Siswanto, Yoga Yuniadi, Ganesja M Harimurti   +3 more
doaj   +1 more source

Digoxin and Heart Failure: Are We Clear Yet?

Cardiovascular Innovations and Applications, 2017
The Digoxin Investigation Group trial has multiple flaws in the trial design for the findings to be universally applicable. Digoxin in low serum concentrations (0.5–0.9 ng/mL) has been shown to decrease mortality in heart failure patients.
Amit Gupta, Melissa Dakkak, Alan Miller
doaj   +1 more source

Digoxin Suppresses Tumor Malignancy through Inhibiting Multiple Src-Related Signaling Pathways in Non-Small Cell Lung Cancer. [PDF]

PLoS ONE, 2015
Non-small cell lung cancer is the predominant type of lung cancer, resulting in high mortality worldwide. Digoxin, a cardiac glycoside, has recently been suggested to be a novel chemotherapeutic agent.
Sheng-Yi Lin, Hsiu-Hui Chang, Yi-Hua Lai, Ching-Hsiung Lin, Min-Hsuan Chen, Gee-Chen Chang, Meng-Feng Tsai, Jeremy J W Chen   +7 more
doaj   +1 more source

The effect of different digoxin concentrations on heart tissue and antioxidant status in iron-overloaded rats

ARYA Atherosclerosis, 2018
BACKGROUND: Thalassaemia is a hereditary disorder and has an economic burden on patients and the government. The most prevalent complication in these patients is iron overload which is followed by cardiomyopathy.
Beydolah Shahouzehi, Hamid Reza Nasri, Yaser Masoumi-Ardakani   +2 more
doaj   +1 more source

THE EFFECT OF ENDOTOXEMIA ON THE PHARMACOKINETICS OF DIGOXIN IN CONSCIOUS MALE RABBITS

Zagazig Journal of Pharmaceutical Sciences, 2002
Multiple organ failure (MOF) is induced by Escherichia coli lipopolysaccharide (LPS) alters the clearance of several drugs in experimental animals and human being.
Atef El-Gharbawy
doaj   +1 more source

The effect of calcium in water hardness on digoxin plasma levels in an experimental rat model [PDF]

ARYA Atherosclerosis, 2020
BACKGROUND: Digoxin is a drug for ventricular rate control in atrial fibrillation (AF). The major challenge in digoxin therapy is to adjust the appropriate concentration range for this drug due to its narrow therapeutic index.
Shabnam Shahsavand, Mohammad Moshirfar, Seyed Hassan Seyed-Sharifi, Mohammad Amin Younessi-Heravi, Reza Ghasemi, Morteza Valaei, Mohsen Yaghubi   +6 more
doaj   +1 more source

Treatment with Digoxin – is it a clinical challenge? A Retrospective Analysis of Hospitalizations due to Digoxin intoxication

Journal of Education, Health and Sport
Introduction and purpose: Digoxin, a cardiac glycoside derived from Digitalis lanata, has stood as a cornerstone in the treatment of various cardiovascular disorders for centuries.
Marcin Wais, Marlena Zając, Dariusz Gruca, Paweł Zalewski, Wiktor Wróblewski, Adam Raabe, Michał Tchórz   +6 more
doaj   +1 more source

Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

BMC Medicine, 2004
Background The ABC transporter P-glycoprotein (P-gp) is recognized as a site for drug-drug interactions and provides a mechanistic explanation for clinically relevant pharmacokinetic interactions with digoxin.
Michaëlsson Karl, Artursson Per, Hallberg Pär, Englund Gunilla, Melhus Håkan   +4 more
doaj   +1 more source

Junctional Bradycardia as Early Sign of Digoxin Toxicity in a Premature Infant with Congestive Heart Failure due to a Left to Right Shunt

American Journal of Perinatology Reports, 2016
Introduction Congestive heart failure due to left to right cardiac shunt is usually managed medically with diuretics, angiotensin converting enzyme inhibitors, and, in some cases, with the addition of digoxin.
Soham Dasgupta, Ashraf M. Aly, Sunil K. Jain   +2 more
doaj   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source