Results 71 to 80 of about 567,985 (207)

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor   +4 more
wiley   +1 more source

Effects of Age, Gender, and Comorbid Diseases on Serum Digoxin Levels During Digoxin Treatment

open access: yesBezmiâlem Science, 2018
Objective:Digoxin is widely used in controlling ventricular rhythm in atrial fibrillation and heart failure. Therapeutic serum levels of digoxin are 0.5–2 ng/mL. Toxicity may occur after acute accidental or suicidal ingestion or with chronic therapy.
Zeynep ÖZTÜRK, Serap ÇUHADAR
doaj   +1 more source

Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion

open access: yesNature Communications, 2023
Nonalcoholic steatohepatitis (NASH) is a progressive disorder with aberrant lipid accumulation and subsequent inflammatory and profibrotic response.
Yoshito Minami   +11 more
doaj   +1 more source

Integrated Phytochemical Characterisation, Pharmacological Evaluation and Computational Investigation of Acampe papillosa Stem Extract

open access: yesAnalytical Science Advances, Volume 7, Issue 2, December 2026.
The pharmacological potential of the methanolic stem extract of Acampe papillosa is evaluated using in vivo and in silico approaches. The extract demonstrates significant anxiolytic, sedative, anti‐inflammatory, and antipyretic activities in experimental models, while molecular docking supports the observed biological effects through favorable ...
Qurratul Ain Sadia   +10 more
wiley   +1 more source

Failed suicide attempt A case report: Digoxin and insulin toxicity, antagonist effect [PDF]

open access: yes, 2017
Digoxin is used to treat heart failure and arrhythmias. Even though its used is decreased, the toxicity of digoxin still remains a problem for physicians.
Alotaibi T   +3 more
core   +1 more source

Mitral regurgitation and decompensated heart failure in a young pregnant pony mare: An aetiological challenge

open access: yesEquine Veterinary Education, Volume 38, Issue 10, Page e676-e685, October 2026.
Summary A 4‐year‐old, 6‐month pregnant, Welsh pony mare presented with severe acute clinical signs including depression, anorexia, pale mucous membranes, tachycardia with a grade 4/6 holosystolic murmur and moderate expiratory dyspnoea with diffuse wheezes. There was no evidence of placentitis or fetal distress.
M. F. David   +4 more
wiley   +1 more source

DIGOXIN TOXICITY IN THAI MEDICAL PATIENTS : CLINICAL MANIFESTATIONS AND AN APPROPRIATE DIAGNOSTIC SERUM LEVEL [PDF]

open access: yes, 2020
. This study considers the clinical manifestations and risk factors of digoxin toxicity and establishes an appropriate cut-off serum level for the diagnosis of toxicity.
Sutthichai Jitapunkul   +3 more
core  

Digoxin Toxicity presented with Right Bundle Branch Block: A Case report of Drug- Drug Interaction [PDF]

open access: yes, 2017
Digoxin, one of the digitalis glycosides has specific effects on the myocardium. The effects of Digoxin in heart failure are mediated by its positive inotropic and neurohormonal deactivating effects, whereas the effects of the drug in atrial arrhythmias ...
R Patel, Pankaj   +4 more
core   +1 more source

Relationship between high serum digoxin levels and toxicity

open access: yes, 1997
A retrospective study of 1,269 patients on digoxin was done to determine the relationship between serum digoxin levels of 3.0 ng/ml or higher and clinical toxicity. Of 1,269 patients, 58 (4.6%) had digoxin serum levels of 3.0 ng/ml or higher.
Oto, O   +5 more
core   +1 more source

Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 9, Page 2151-2156, September 2026.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio   +11 more
wiley   +1 more source

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