Results 81 to 90 of about 567,985 (207)

Supratherapeutic drug concentration triggers: A novel data‐driven approach to assess their value for medication safety surveillance in intensive care

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3191-3201, September 2026.
Aims Electronic triggers (e‐triggers) are used as screening signals to detect potential adverse drug events (ADEs) and offer an effective system level approach for medication safety surveillance. Their clinical utility is typically evaluated through time‐consuming manual chart review by experts, limiting implementation.
Anne Paulien Langermans, Izak A. R. Yasrebi‐de Kom, Dylan Wayne de Lange, Nicolette Fransisca de Keizer, Joanna E. Klopotowska, on behalf of the RESCUE Study group, C. S. C. Bouman, E. N. van Roon, P. F. Schutte, J. ten Cate, D. van Balen, S. Hendriks, C. Lau, W. J. Vermeijden, A. Beishuizen, J. B. Masselink, P. E. Spronk, H. J. M. van Kan, P. W. de Feiter, E. J. Wils, A. Wieringa, A. J. Valkenburg, W. M. van den Bergh, M. H. Renes, W. Bult, E. de Jonge, M. Hoeksema, E. J. Wesselink, I. M. Purmer, B. E. Bosma, S. H. W. van Bree, H. J. W. Lammers, R. J. Bosman, E. J. F. Franssen, A. Karakus, M. Sigtermans, E. M. Kuck, D. A. Dongelmans, M. J. H. Aries, E. V. Uijtendaal, M. C. Reuland   +40 more
wiley   +1 more source

The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat [PDF]

, 2010
pharmaceutic
Lowes, Simon, Anna-lena Ungell, Nicholas L. Simmons, Haslam, Iain S., Johan E. Karlsson, Iain S. Haslam, Ungell, Anna-Lena, Hilgendorf, Constanze, Ungell, Anna Lena, Simon Lowes, Fihn, Britt-Marie, Simmons, Nicholas L., Constanze Hilgendorf, Fihn, Britt Marie, Britt-marie Fihn, Karlsson, Johan E., Lowes, Fihn, Karlsson, Hilgendorf, Haslam, Simmons, Ungell   +22 more
core   +1 more source

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Digoxin Dilemma: Diagnosing Toxicity Amidst Dementia

Digoxin, a cardiac glycoside and sodium–potassium adenosine triphosphatase inhibitor, has a narrow therapeutic index and is primarily prescribed for conditions such as systolic heart failure and atrial fibrillation.
Bajoria, Parth Sushil, Nookala, Vinod
core   +1 more source

Neurocardiology: Brain–Heart Interactions in the Heart

MedComm, Volume 7, Issue 9, September 2026.
The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang, Hao Jia, Han Han, Jiangping Song   +3 more
wiley   +1 more source

Clinical features and successful management of suicidal digoxin toxicity without use of digoxin-specific antibody (Fab) fragments – is it possible?

, 2011
A retrospective study of 147 consecutive cases of suicidal digoxin poisoning was undertaken in order to determine the severity and outcome of toxicity without use of digoxin-specific Fab fragments.
Babak Mostafazadeh, Hossein Sanaei-Zadeh, Zahra Valian, Nasim Zamani, Hoorvash Farajidana   +4 more
core   +1 more source

Semi‐Mechanistic Joint Population Pharmacokinetic Modeling of the Novel Antituberculosis Drug Sorfequiline and Its Metabolite M3 in Healthy Volunteers

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACTSorfequiline is a novel diarylquinoline in development for treatment of tuberculosis. In vitro data suggest metabolism via CYP3A4, carrying the potential for presystemic metabolism and drug–drug interactions. Its major metabolite, M3, is pharmacologically active.
Jose M. Calderin, Jerry Nedelman, David H. Salinger, Thanakorn Vongjarudech, Paolo Denti, Elin M. Svensson   +5 more
wiley   +1 more source

Table1_Review: Failure of current digoxin monitoring for toxicity: new monitoring recommendations to maintain therapeutic levels for efficacy.docx

, 2023
The current recommendations for monitoring digoxin, a narrow therapeutic index drug, are limited to confirming medication use or investigating suspicion of toxicity and fail our oath to do no harm.
Joel Rosenberg (16481859), Mary E. Money (16481868), Sridhar Rao Gona (16481856), Ria C. Fyffe-Freil (16481862), Sridhar Rao Gona, Janet M. Kozakiewicz, Janet M. Kozakiewicz (16481865), Ria C. Fyffe-Freil, Mary E. Money, Joel Rosenberg   +9 more
core   +1 more source

Acute ellipsoid zone thickening: A sign of probable digoxin toxicity?

Indian Journal of Ophthalmology. Case Reports
A 62-year-old gentleman presented with blurred vision in both eyes associated with excessive sleepiness and headache for 5 days. Optical coherence tomography (OCT) showed thickening of ellipsoid zone (EZ) with subtle separation from retinal pigment ...
B C Pradeep, Pradeep Sagar, Mahesh P Shanmugam, Parvathy Prabhakaran, Suchitra Biswal   +4 more
doaj   +1 more source

Net Renal Drug Secretion Critically Requires Significant Contribution of Basal Uptake Transporters: Perspective From Mechanistic Kidney Model Simulation and Integration of Clinical and In Vitro Data

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Renal clearance (CLr) is the net outcome of glomerular filtration, secretion, and reabsorption, which makes the quantitative requirements for net renal secretion difficult to infer from simple clearance models. Using a mechanistic kidney model (MechKiM), we simulated blood‐referenced CLr (CLr,b) for 30,000 virtual drugs (neutral, monoanionic ...
Toshiaki Tsuchitani, Masatoshi Tomi, Yuichi Sugiyama   +2 more
wiley   +1 more source