Results 91 to 100 of about 264 (104)
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Dihematoporphyrin Ether-Induced photosensitivity in laryngeal papilloma patients
Lasers in Surgery and Medicine, 1990AbstractTwenty‐six patients with recurrent laryngeal papillomatosis received 2.5 mg/kg of Dihematoporphyrin Ether (DHE) intravenously prior to photodynamic therapy. All patients experienced some degree of photosensitivity, the only known side effect of DHE.Reported reactions included mild erythema and inflammation (88%), swelling (58%), blistering (23%)
Allan L Abramson, Mark J Shikowitz
exaly +3 more sources
THE MEASUREMENT OF DIHEMATOPORPHYRIN ETHER CONCENTRATION IN TISSUE BY REFLECTANCE SPECTROPHOTOMETRY
Photochemistry and Photobiology, 1987AbstractThe in vivo quantitation of local photosensitizer concentration is an important problem in photodynamic therapy because tumor response depends on this parameter. This paper describes a new method for measuring dihematoporphyrin ether (DHE) concentration by reflectance spectrophotometry—a technique which could be applied to other ...
Michael S Patterson +2 more
exaly +3 more sources
American Journal of Ophthalmology, 2006
Long-term evaluation of dihematoporphyrin ether (DHE) safety and efficacy as photodynamic therapy (PDT) for patients with corneal neovascularization (KNV).Prospective multi-center interventional case series.Seven patients were enrolled after Institutional Review Board approval and a detailed informed consent were obtained.
John D Sheppard +2 more
exaly +3 more sources
Long-term evaluation of dihematoporphyrin ether (DHE) safety and efficacy as photodynamic therapy (PDT) for patients with corneal neovascularization (KNV).Prospective multi-center interventional case series.Seven patients were enrolled after Institutional Review Board approval and a detailed informed consent were obtained.
John D Sheppard +2 more
exaly +3 more sources
ON THE PREPARATION and PROPERTIES OF DIHEMATOPORPHYRIN ETHER, THE TUMOR‐LOCALIZING COMPONENT OF HPD*
Photochemistry and Photobiology, 1985Abstract—A porphyrin mixture derived from hematoporphyrin and termed HPD (hematoporphyrin derivative) is used for localization and therapy of tumors. The major localizing component of HPD has been provisionally identified as a dihematoporphyrin ether (DHE).
David Kessel
exaly +3 more sources
Photochemistry and Photobiology, 1987
Abstract Natural history studies of patients with macular subretinal neovascularization as a complication of age‐related macular degeneration have shown a poor visual outcome, with 77% losing more than 4 lines of vision and 64% losing 6 lines at 24 months after presentation.
E L, Thomas, M, Langhofer
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Abstract Natural history studies of patients with macular subretinal neovascularization as a complication of age‐related macular degeneration have shown a poor visual outcome, with 77% losing more than 4 lines of vision and 64% losing 6 lines at 24 months after presentation.
E L, Thomas, M, Langhofer
exaly +3 more sources
Photochemistry and Photobiology, 1988
Abstract— Photodynamic therapy (PDT) is a new modality for treatment of malignancy. In this paper, we reported the effect of UV activated dihematoporphyrin ether (DHE) on [3H] thymidine uptake and DNA synthesis in murine bladder tumor cells,MBT–2. Exponentially growing cells were pretreated with 0.05–5μg/ml of DHE for 30 min in complete darkness prior ...
Michael T Tseng +2 more
exaly +3 more sources
Abstract— Photodynamic therapy (PDT) is a new modality for treatment of malignancy. In this paper, we reported the effect of UV activated dihematoporphyrin ether (DHE) on [3H] thymidine uptake and DNA synthesis in murine bladder tumor cells,MBT–2. Exponentially growing cells were pretreated with 0.05–5μg/ml of DHE for 30 min in complete darkness prior ...
Michael T Tseng +2 more
exaly +3 more sources
The binding of dihematoporphyrin ether (photofrin II) to human serum albumin
Clinica Chimica Acta, 1985The variable aggregation of porphyrins such as Hp and Hpd introduces uncertainties and errors into attempts to measure their binding to proteins. Methods such as dialysis, ultrafiltration and gel chromatography, so frequently used, proved to be unreliable when applied to the binding of Hp to serum albumin. Quenching of tryptophan fluorescence will only
J, Moan, C, Rimington, A, Western
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Photochemistry and Photobiology, 1987
Abstract Results of dihematoporphryin ether (DHE) uptake and fluorescence kinetics show that the concentration in the pancreas is on the order of 40‐60 μg DHE g−1 of tissue at an injected dose of 40 mg kg−1. Previously concentrations on this order have primarily been found in organs of the reticuloendothelial system.
T S, Mang, T J, Wieman
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Abstract Results of dihematoporphryin ether (DHE) uptake and fluorescence kinetics show that the concentration in the pancreas is on the order of 40‐60 μg DHE g−1 of tissue at an injected dose of 40 mg kg−1. Previously concentrations on this order have primarily been found in organs of the reticuloendothelial system.
T S, Mang, T J, Wieman
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Photochemistry and Photobiology, 1987
Abstract Fluorescence spectroscopy was utilized to investigate the equilibrium interaction of dihem‐atoporphyrin ether(s) (DHE) with binary and ternary phospholipid mixtures of defined composition in order to define the roles of net negative surface charge and lateral phase separations in DHE‐membrane partitioning. Binary phospholipid mixtures employed
S E, Kendrick +5 more
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Abstract Fluorescence spectroscopy was utilized to investigate the equilibrium interaction of dihem‐atoporphyrin ether(s) (DHE) with binary and ternary phospholipid mixtures of defined composition in order to define the roles of net negative surface charge and lateral phase separations in DHE‐membrane partitioning. Binary phospholipid mixtures employed
S E, Kendrick +5 more
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Lasers in Surgery and Medicine, 1993
AbstractPhotodynamic therapy (PDT) is being evaluated in experimental clinical trials in patients with peritoneal malignancies. Some patients require partial small bowel resection with re‐anastomosis prior to PDT because of bulky tumor or focal involvement of the small bowel by tumor.
T F, DeLaney +4 more
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AbstractPhotodynamic therapy (PDT) is being evaluated in experimental clinical trials in patients with peritoneal malignancies. Some patients require partial small bowel resection with re‐anastomosis prior to PDT because of bulky tumor or focal involvement of the small bowel by tumor.
T F, DeLaney +4 more
openaire +2 more sources