Biodistribution of Indium 111-Labeled Dihematoporphyrin Ether in Papillomas and Body Tissues: Relevance to Photodynamic Therapy [PDF]
JAMA Otolaryngology, 1989 Hematoporphyrin derivative and its newly purified form, dihematoporphyrin ether, have been shown to localize selectively in malignant tissues and virally induced papillomas. Its use as a probe to distinguish tumors from normal tissues has been largely based on its fluorescence when activated by UV light.
M J Shikowitz, Mark J Shikowitz
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Pharmacokinetic Studies of Hematoporphyrin Derivatives on Rat Hepatocytes. Protoporphyrin Dimethyl Ester Hematoporphyrin Ether versus Dihematoporphyrin Ether-Free Hematoporphyrin Derivative [PDF]
Biological Chemistry Hoppe-Seyler, 1991 Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
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Severe but temporary injury to rabbit orbicularis oculi muscle using dihematoporphyrin ether and laser photochemomyectomy [PDF]
Movement Disorders, 1992 AbstractThe use of local dihematoporphyrin ether (DHE) injections, followed by laser light activation, was investigated as a potential permanent myectomy treatment for muscle spasms, in particular blepharospasm and hemifacial spasm. DHE was injected into the eyelids of rabbits, followed by laser activation, as used in photochemotherapy. Four days after
Linda K Mcloon, J D Wirtschafter
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Response of Black and White Guinea Pig Skin to Photodynamic Treatment Using 514-nm Light and Dihematoporphyrin Ether [PDF]
Archives of Dermatology, 1990 Differences in skin pigmentation may significantly affect light penetration during photodynamic therapy. This study evaluated the effect of skin pigmentation on dermatotoxic reaction to photodynamic therapy utilizing the photosensitizer dihematoporphyrin ether.
Gary R Kantor, Angelo Russo
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Biodistribution of Indium-III Dihematoporphyrin Ether in Papillomas and Body Tissues and its Relevance to Photodynamic Therapy [PDF]
, 1988 Hematoporphyrin derivative (HPD) and its newly purified form, dihematoporphyrin ether (DUE) have been shown to selectively localize in malignant tissues and virally induced papillomas (Sliikowitz et.al.). Its use as a probe to distinguish tumors from normal tissues has been largely based on its fluorescence when activated by ultraviolet light.
Mark J Shikowitz
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A Langmuir-Blodgett study of the orientation of the cancer photoradiation therapy drug dihematoporphyrin ether at water-air and water-fatty-acid-air interfaces [PDF]
Thin Solid Films, 1986 Abstract The fluorescent molecule dihematoporphyrin ether (DHE), which is known to become sequestered in cells and which is currently being used for “photoradiation” cancer therapy in clinical trials, may organize into two-dimensional arrays at a water-membrane interface.
Dietmar Möbius
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Dihematoporphyrin Ether Clearance in Primate Bladders [PDF]
Journal of Urology, 1986 The techniques of in vivo tissue fluorescence photometry and chemical extractions of DHE, which have been recently developed in our laboratory, were employed to study DHE uptake and clearance in the primate bladders. Data show these techniques are readily applicable in studying porphyrin uptake and clearance in primate bladders.
U O, Nseyo, T S, Mang, W R, Potter
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PROTECTION AGAINST DIHEMATOPORPHYRIN ETHER PHOTOSENSITIVITY
Photochemistry and Photobiology, 1988AbstractAmelioration of dihematoporphyrin ether (DHE) induced skin photosensitivity by medications either suspected or known to influence porphyrin metabolism or inflammatory response was evaluated in 357 female athymic NCR‐nude mice (308 study animals, 49 controls) in 56 separate study groups.
Seth Steinberg, E Glatstein
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Dihematoporphyrin Ether-Induced photosensitivity in laryngeal papilloma patients
Lasers in Surgery and Medicine, 1990AbstractTwenty‐six patients with recurrent laryngeal papillomatosis received 2.5 mg/kg of Dihematoporphyrin Ether (DHE) intravenously prior to photodynamic therapy. All patients experienced some degree of photosensitivity, the only known side effect of DHE.Reported reactions included mild erythema and inflammation (88%), swelling (58%), blistering (23%)
A L Abramson, M J Shikowitz
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An Investigation Of Photodynamic Therapy In The Treatment Of Pancreatic Carcinoma: Dihematoporphyrin Ether Uptake And Photobleaching Kinetics [PDF]
SPIE Proceedings, 1988 Results of dihematoporphyrin ether (DHE) uptake and fluorescence kinetics show that the concentration in the pancreas is on the order of 40-60 μg DHE/g of tissue at an injected dose of 40 mg/kg. Previously concentrations on this order have only been found in organs of the reticuloendothelial system.
Thomas S. Mang, Thomas J. Wieman
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