Results 1 to 10 of about 275 (98)

Development of Novel Tetrapyrrole Structure Photosensitizers for Cancer Photodynamic Therapy [PDF]

Bioengineering, 2022
The effectiveness of photodynamic therapy (PDT) is based on the triad effects of photosensitizer (PS), molecular oxygen and visible light on malignant tumors.
Natalia Plekhova, Olga Shevchenko, Oksana Korshunova, Aleksandra Stepanyugina, Ivan Tananaev, Vladimir Apanasevich   +5 more
doaj   +3 more sources

Teraphtal (sodium salt of cobalt 4,5-carboxyphthalocyanine) Decreases Sensitivity of Tumor Cells to Anthracycline Antibiotics and Mitoxantrone in Vitro [PDF]

Клиническая онкогематология, 2018
Background. Anthracycline antibiotics (AA) are widely used in clinical oncohematology. As is well known АА cytotoxicity diminishes in the presence of hemin (FePPIX), an endogenous metalloporphyrine. Aim.
Tat’yana Aleksandrovna Sidorova, O. O. Ryabaya, V. V. Tatarskii, D. A. Khochenkov, E. S. Ivanova, O. L. Kaliya   +5 more
doaj   +3 more sources

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Mechanism‐Guided Engineering of Upconversion Nanoparticles for Antibacterial Phototherapy: From Photonic Principles to Translational Nanosystems

Small, EarlyView.
This review provides a systematic overview of the field of antibacterial PhotoDynamic Therapy (aPDT) triggered by upconversion nanoparticles (UCNPs), focusing on the mechanisms and the key factors that define their efficacy for generating bactericidal species upon NIR‐light activation.
Zhe Li, Calum Johnston, Barbara Lonetti, Clément Roux   +3 more
wiley   +1 more source

Harnessing the nonthermal effects of ultrasound for cancer treatment: From mechanisms to applications

Smart Molecules, EarlyView.
Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang, Huan Tang, Yue Pan, Mingle Li, Weijie Zhao, Kai Liu   +5 more
wiley   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Efficacy and Safety of DVDMS‐Photodynamic Therapy for Dysphagia in Advanced Esophageal Cancer: A Phase II Clinical Trial

Cancer Science, EarlyView.
In this single‐arm Phase II trial, cosiporfin sodium‐mediated photodynamic therapy demonstrated efficacy in alleviating dysphagia and improving quality of life for patients with advanced esophageal cancer, with rapid onset, sustained efficacy, and good tolerability.
Jun Zhou, Shegan Gao, Jiajia Yuan, Hao Chen, Yongqian Shu, Huizhen Fan, Yanshuo Cao, Tanyou Shan, Caihong Dong, Hao Zhang, Qingting Song, Baobao Xin, Hao Zhang, Zhihao Lu, Lin Shen   +14 more
wiley   +1 more source

The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models

Photochemistry and Photobiology, EarlyView.
This review evaluates Photodynamic Therapy (PDT) in in vivo head and neck cancer models. PDT effectively generates ROS, reducing tumor growth, cell proliferation and angiogenesis while enhancing survival and immune responses. However, methodological heterogeneity highlights the urgent need for standardized dosimetric protocols to ensure reproducibility
Bibiana Padilha de Menezes da Silva, Rebeca Barros Nascimento, Giovanna Lopes Carvalho, Rebeca Boltes Cecatto, Maria Stella Moreira, Maria Fernanda Setúbal Destro Rodrigues   +5 more
wiley   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, Volume 4, Issue 3, September 2026.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Nanomaterial‐Mediated Radiotherapy–Immunotherapy Combinations: Breaking Immunosuppression and Revolutionizing Cancer Treatment

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
Nanomaterials integrate radiotherapy and immunotherapy by enhancing radiosensitivity, remodeling the immunosuppressive tumor microenvironment, and promoting systemic antitumor immunity. This review summarizes the latest strategies of nanomaterial‐mediated combinations (RT, immunotherapy, IRT) and highlights future directions for overcoming clinical ...
Peijie Li, Xiangqin Wang, Sisi He, Hu Ma
wiley   +1 more source