Results 11 to 20 of about 310 (139)
Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley +1 more source
Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang +4 more
wiley +1 more source
This review elucidates URB design strategies, including genetic and physicochemical modifications, while dissecting the synergistic mechanisms governing spatiotemporal control. It further evaluates applications in targeted drug delivery, gene modulation, and immunotherapy, finally offering perspectives on overcoming translational barriers for clinical ...
Xueyao Wang +5 more
wiley +1 more source
AIEgens: An Exemplary Template for “One‐for‐All” Multimodal Phototheranostics
This review establishes a consensus that AIEgens serve as a quintessential template for “one‐for‐all” multimodal phototheranostics and systematically articulates the underlying rationale from a photophysical perspective. It comprehensively examines corresponding molecular engineering principles and performance optimization tactics, framed within the ...
Miaomiao Kang +9 more
wiley +1 more source
ABSTRACT Diabetic wound infections are a common complication of diabetes, which severely impact patients' quality of life. Effective treatment of diabetic wound infections remains one major challenge in the clinic, partially due to the formation of bacterial biofilm and antibiotic resistance.
Liang Zhou +8 more
wiley +1 more source
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source
Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases
ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan +5 more
wiley +1 more source
In Vivo Efficacy of Zinc Phthalocyanine Nanocarriers IN Photodynamic Therapy of Cancer
Zinc phthalocyanines are photosensitizing agents used in photodynamic therapy. Their incorporation into nanosystems enables their encapsulation, targeting, and functionalization, optimizing their therapeutic activity. The results highlight their therapeutic potential, reinforcing their relevance as an innovative strategy in cancer treatment and as a ...
Adrian Lima Roberto +4 more
wiley +1 more source
Implanted Miniature Light Devices for Phototherapeutics
Modern phototherapeutics has many attractive features; however, the shallow penetration of light into skin and tissue is an inherent physical limitation that restricts usage to superficial sites of disease. To mitigate this major problem, researchers and clinicians are actively developing miniature implanted light devices that can be implanted within a
Hailey S. Sanders +5 more
wiley +1 more source
FLASH‐PDT uses strongly‐absorbing photosensitizers and pulsed lasers to saturate the photosensitizer absorption at ≈1‐cm tissue depths. This allows for the generation of [ROS] above the necrosis threshold level for tumors, while maintaining [ROS] in peritumoral tissues below that threshold, even when the tumor‐to‐peritumoral tissue ratio is as low as 2.
Luis G. Arnaut +3 more
wiley +1 more source

