Results 101 to 110 of about 130,200 (126)

Transcutaneous Determination of Tissue Dihematoporphyrin Ether Content

Archives of Dermatology, 1991
• Photodynamic therapy involves the use of light of appropriate wavelength to excite a photosensitizer resulting in tissue destruction. The photosensitizer dihematoporphyrin ether is selectively retained in tumors allowing for tumor destruction while sparing normal structures. Accessibility of skin tumors makes them well suited for photodynamic therapy.

exaly   +2 more sources

Dihematoporphyrin Ether-Induced photosensitivity in laryngeal papilloma patients

Lasers in Surgery and Medicine, 1990
AbstractTwenty‐six patients with recurrent laryngeal papillomatosis received 2.5 mg/kg of Dihematoporphyrin Ether (DHE) intravenously prior to photodynamic therapy. All patients experienced some degree of photosensitivity, the only known side effect of DHE.Reported reactions included mild erythema and inflammation (88%), swelling (58%), blistering (23%)
M J Shikowitz, A L Abramson
exaly   +3 more sources

In Vitro Photosensitization of Human Head and Neck Squamous Cancer Cells by Dihematoporphyrin‐Ether

Otolaryngology - Head and Neck Surgery, 1988
In vitro experiments were performed to evaluate the direct cytotoxic and photosensitizing effects of dihematoporphyrin‐ether (DHE) on the head and neck squamous cancer cell line, UM‐SCC‐38. Normal fibroblasts, normal cultured keratinocytes, and the UM‐MEL‐1 pigmented malignant melanoma cell line were used as controls.
Thomas Carey
exaly   +3 more sources

THE MEASUREMENT OF DIHEMATOPORPHYRIN ETHER CONCENTRATION IN TISSUE BY REFLECTANCE SPECTROPHOTOMETRY

Photochemistry and Photobiology, 1987
AbstractThe in vivo quantitation of local photosensitizer concentration is an important problem in photodynamic therapy because tumor response depends on this parameter. This paper describes a new method for measuring dihematoporphyrin ether (DHE) concentration by reflectance spectrophotometry—a technique which could be applied to other ...
Michael Patterson
exaly   +3 more sources

Argon Laser Photodynamic Therapy of Human Corneal Neovascularization After Intravenous Administration of Dihematoporphyrin Ether

American Journal of Ophthalmology, 2006
Long-term evaluation of dihematoporphyrin ether (DHE) safety and efficacy as photodynamic therapy (PDT) for patients with corneal neovascularization (KNV).Prospective multi-center interventional case series.Seven patients were enrolled after Institutional Review Board approval and a detailed informed consent were obtained.
Randy J Epstein, Frank A Lattanzio, Patricia B Williams   +2 more
exaly   +3 more sources

Biodistribution of Indium 111-Labeled Dihematoporphyrin Ether in Papillomas and Body Tissues: Relevance to Photodynamic Therapy

JAMA Otolaryngology, 1989
Hematoporphyrin derivative and its newly purified form, dihematoporphyrin ether, have been shown to localize selectively in malignant tissues and virally induced papillomas. Its use as a probe to distinguish tumors from normal tissues has been largely based on its fluorescence when activated by UV light.
M J Shikowitz, Mark J Shikowitz
exaly   +3 more sources

ON THE PREPARATION and PROPERTIES OF DIHEMATOPORPHYRIN ETHER, THE TUMOR‐LOCALIZING COMPONENT OF HPD*

Photochemistry and Photobiology, 1985
Abstract—A porphyrin mixture derived from hematoporphyrin and termed HPD (hematoporphyrin derivative) is used for localization and therapy of tumors. The major localizing component of HPD has been provisionally identified as a dihematoporphyrin ether (DHE).
David Kessel
exaly   +3 more sources

Response of Black and White Guinea Pig Skin to Photodynamic Treatment Using 514-nm Light and Dihematoporphyrin Ether

Archives of Dermatology, 1990
• Differences in skin pigmentation may significantly affect light penetration during photodynamic therapy. This study evaluated the effect of skin pigmentation on dermatotoxic reaction to photodynamic therapy utilizing the photosensitizer dihematoporphyrin ether. Black and white guinea pigs were given 10 mg/kg of dihematoporphyrin ether, depilated, and
Gary R Kantor
exaly   +4 more sources

Pharmacokinetic Studies of Hematoporphyrin Derivatives on Rat Hepatocytes. Protoporphyrin Dimethyl Ester Hematoporphyrin Ether versus Dihematoporphyrin Ether-Free Hematoporphyrin Derivative

Biological Chemistry Hoppe-Seyler, 1991
Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both, H, Häberlein, A M, Gressner, I, Sieg, M O, Doss   +4 more
exaly   +3 more sources

Severe but temporary injury to rabbit orbicularis oculi muscle using dihematoporphyrin ether and laser photochemomyectomy

Movement Disorders, 1992
AbstractThe use of local dihematoporphyrin ether (DHE) injections, followed by laser light activation, was investigated as a potential permanent myectomy treatment for muscle spasms, in particular blepharospasm and hemifacial spasm. DHE was injected into the eyelids of rabbits, followed by laser activation, as used in photochemotherapy. Four days after
Linda K McLoon, J D Wirtschafter
exaly   +3 more sources