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Capsaicinoids and capsinoids of chilli pepper as feed additives in livestock production: Current and future trends. [PDF]

open access: yesAnim Nutr
Gutiérrez-Chávez V   +5 more
europepmc   +1 more source
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Dihydrocapsaicin-induced hypothermia and substance P depletion

European Journal of Pharmacology, 1982
Administration of dihydrocapsaicin to rats resulted in a dose-dependent (0.5-10 mg/kg s.c.) hypothermia. Dihydrocapsaicin was approximately 65% more effective in producing hypothermia than capsaicin. Desensitization and cross-tolerance occurred to the hypothermic effects of both capsaicin and dihydrocapsaicin.
M S, Miller   +3 more
openaire   +2 more sources

Dihydrocapsaicin induces translational repression and stress granule through HRI-eIF2α phosphorylation axis

Biochemical and Biophysical Research Communications, 2022
Stress granules (SGs) are cytoplasmic biomolecular condensates that are formed against a variety of stress conditions when translation initiation is perturbed. SGs form through the weak protein-protein, protein-RNA, and RNA-RNA interactions, as well as through the intrinsically disordered domains and post-translation modifications within RNA binding ...
Koushitak De   +4 more
openaire   +2 more sources

The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells

Cancer Letters, 1989
A crude mixture of capsaicinoids (CAPs) from Capsicum frutrescens, capsaicin (C) and dihydrocapsaicin (DC) but not 4-methyl-dihydrocapsaicin (MC), a synthetic homolog of DC, were mutagenic in the V79 assay. Oxidative metabolism of C and DC by microsomes or ferricyanide yielded a dimer of C or DC.
T, Lawson, P, Gannett
openaire   +2 more sources

Quantitative microanalysis of capsaicin, dihydrocapsaicin and nordihydrocapsaicin using mass fragmentography

Journal of Chromatography A, 1976
A mass fragmentographic method for the quantitative microanalysis of capsaicin, dihydrocapsaicin and nordihydrocapsaicin in the fruits of Capsicum annuum has been developed. The molecular ions at m/e 377, 379 and 365 in the mass spectra were used for monitoring the trimethylsilyl derivatives of capsaicin, dihydrocapsaicin and nordihydrocapsaicin ...
Kap-Rang Lee   +4 more
openaire   +2 more sources

Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats

Toxicology and Applied Pharmacology, 1984
Gastrointestinal absorption of capsaicin and dihydrocapsaicin was studied in rats in vivo and in situ. Rapid absorption of capsaicin or dihydrocapsaicin from stomach and small intestine occurred in vivo. About 85% of the dose was absorbed in the gastrointestinal tract within 3 hr.
T, Kawada   +3 more
openaire   +2 more sources

Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines

Free Radical Biology and Medicine, 2010
We reported that dihydrocapsaicin (DHC) induces autophagy in a catalase-regulated manner. In this study, we further examined the role of DHC-induced autophagy in lung cell lines. DHC-induced cytotoxicity was higher in WI38 and H1299 cells than in H460 and A549 cells, and was related to the loss of cell membrane integrity.
Cheol-Hee, Choi   +2 more
openaire   +2 more sources

Comparison of in vitro metabolism and cytotoxicity of capsaicin and dihydrocapsaicin

Journal of Chromatography B, 2016
Capsaicin and dihydrocapsaicin are the major active components in pepper spray products, which are widely used for law enforcement and self-protection. The use of pepper sprays, due to their irreversible and other health effects has been under a strong debate.
Halme, Mia   +6 more
openaire   +2 more sources

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