Results 191 to 200 of about 36,573 (221)

Medizinische Chemie der L‐Typ‐Calcium‐Kanalblocker: Dihydropyridine und Nicht‐Dihydropyridine

Pharmazie in unserer Zeit, 2005
AbstractNach der ersten Beschreibung einer physiologischen Bedeutung von Calciumionen an kardialen Geweben im Jahre 1883 von Ringer haben sich die Kenntnisse um die Regulation dieses wichtigen Regulators enorm erweitert. Die hier vorgestellten Calcium‐Kanalblocker sind alle Vasodilatatoren, aber dies in einem unterschiedlichen Ausmaß. Während die Nicht‐
Manfred Schubert‐Zsilavecz, Holger Stark   +1 more
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Convenient Construction of Indanedione‐Fused 2,5‐Dihydropyridines, 4,5‐Dihydropyridines, and Spirooxindolines

European Journal of Organic Chemistry, 2016
A cycloaddition reaction promoted by the Lewis acid BF3·OEt2 between 2‐arylidene‐1,3‐indanediones and β‐enamino esters, generated by the addition of arylamines to dimethyl acetylenedicarboxylate, gave densely substituted 1,4‐diphenyl‐4,5‐dihydro‐1H‐indeno[1,2‐b]pyridines in satisfactory yields.
Wen‐Juan Yang, Jing Zhang, Jing Sun, Chao‐Guo Yan   +3 more
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ChemInform Abstract: DIHYDROPYRIDINES, II. SYNTHESIS OF 1,4‐DIHYDROPYRIDINES WITH BRIDGEHEAD NITROGEN

Chemischer Informationsdienst, 1978
AbstractMichael‐Addition der N‐verbrückten Enaminocarbonylverbindungen (II) an die Alkylidenacetessigester (I) führt in einer modifizierten Hantzsch‐Pyridin‐ Synthese zu den 1,4‐Dihydropyridinen (III) mit Brückenkopf‐N‐Atom.
H. MEYER, F. BOSSERT, H. HORSTMANN
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Dihydropyridine precursors of elastin crosslinks

Biochimica et Biophysica Acta (BBA) - General Subjects, 1978
Dihydrodesmosine and dihydroisodemosine are dihydropyridines which are believed to be the immediate biosynthetic precursors of desmosine and isodesmosine, the stable pyridinium ion crosslinks of elastin. It has recently been reported that appreciably amounts of dihydrodesmosine and dihydroisodesmosine accumulate in elastin.
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(Dihydropyridine)iron tricarbonyl complexes

Journal of Organometallic Chemistry, 1975
Abstract ( N -Carboalkoxy-1,2-dihydropyridine)iron tricarbonyl complexes have been isolated by treatment of either N -carboalkoxy-1,2 or -1,4-dihydropyridines with diiron ennecarbonyl. The organic ligand was liberated from these complexes by use of trimethylamine oxide.
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DIHYDROPYRIDINES AND PARKINSONISM

The Lancet, 1986
J, Traber, F, Hoffmeister, J, Kuhlmann
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Dihydropyridines As Antihypertensive Agents

1986
Vascular smooth muscle tone is increased by inward transmembrane flux of Ca2+ through voltage-dependent and receptor-operated channels, as well as from intracellular stores. Calcium entry blockers selectively and reversibly reduce the influx of Ca2+ into the cell through the cell membrane and from bound sites within the cell.
C. Rosendorff, C. Goodman
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1,4-Dihydropyridine

Journal of the American Chemical Society, 1965
Newell C. Cook, James E. Lyons
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Dihydropyridines and vascular diseases.

Zeitschrift fur Kardiologie, 1992
Ca antagonists of the dihydropyridine class (DHPs) are a heterogeneous group of drugs that interfere with Ca entry into vascular smooth muscle cells of resistance arterioles through type-L calcium channels producing arteriolar vasodilation. This leads to a reduction of vascular tone and, therefore, they have been successfully used in the treatment of ...
J, Tamargo, E, Delpón
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Dihydropyridines

2006
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