Results 111 to 120 of about 35,924 (294)

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. [PDF]

, 2018
Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown.
Aguirre, Aitor, Chen, Haodong, Chour, Tony, Holmström, Alexandra, Itzhaki, Ilanit, Jain, Mohit, Kim, Youngkyun, Lehmann, Kim, Ndoye, Babacar C, Neofytou, Evgenios, Qin, Xulei, Shukla, Praveen, Wu, Joseph C, Xiao, Dan, Yang, Huaxiao, Zhang, Joe Z, Zhao, Mingtao, Zhao, Xin, Zhuge, Yan, Zimmermann, Wolfram-Hubertus   +19 more
core   +3 more sources

Sleep Alters the Velocity of Physiological Brain Pulsations in Humans

Advanced Science, EarlyView.
Sleep alters I/CSF oscillatory flow, driven by increased respiratory (29%) and vasomotor pulsation (21%) velocities, while cardiovascular pulsations decreased by (22%). Velocity is quantified using optical flow analysis of MREG data. Spectral power increases alongside these pulsations (spatial correlation, r = 0.35 and r = 0.39, respectively ...
Ahmed Elabasy, Heta Helakari, Tommi Väyrynen, Zalán Rajna, Niko Huotari, Lauri Raitamaa, Ville Isokoski, Matti Järvelä, Mika Kaakinen, Johanna Piispala, Mika Kallio, Vesa Korhonen, Tapio Seppänen, Vesa Kiviniemi   +13 more
wiley   +1 more source

Segmental absence of intestinal musculature with metachronous bowel perforations in an infant

Journal of Pediatric Surgery Case Reports, 2018
Segmental absence of intestinal musculature is a rare condition. A female patient was born at 39 weeks gestational age with birth weight of 2,900 g. The patient was prenatally diagnosed as having segmental bowel distension in the fetal stage.
Noboru Oyachi, Takeyuki Suzuki, Takaki Emura, Kazuko Obana, Atsushi Nemoto, Atsushi Naito, Toshio Oyama   +6 more
doaj   +1 more source

What went wrong? The flawed concept of cerebrospinal venous insufficiency [PDF]

, 2013
In 2006, Zamboni reintroduced the concept that chronic impaired venous outflow of the central nervous system is associated with multiple sclerosis (MS), coining the term of chronic cerebrospinal venous insufficiency ('CCSVI'). The diagnosis of 'CCSVI' is
Al-Omari MH, Alikhani K, Bartomolei I, Batson OV, Baumgartner RW, Benabid AL, Doepp F, Eckenhoff JE, Hempel KJ, Hojnacki D, Kipshidze N, Kostecki J, Lang J, Lang J, Ludyga T, Malagoni AM, Masuhr F, Mayer C, Nicolaides AB, Oberwahrenbrock T, Odake G, Oktar SO, Salvi F   +22 more
core   +2 more sources

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Subarachnoid hemorrhage caused by vertebrobasilar dolichoectasia complicated with basilar artery dissecting aneurysm: one case report

Chinese Journal of Contemporary Neurology and Neurosurgery, 2016
DOI: 10.3969/j.issn.1672-6731.2016.12 ...
Jing-wei LI, Si-shi XIANG, Feng LING, Hong-qi ZHANG, Gui-lin LI   +4 more
doaj  

Small Intestinal Obstruction Caused by a Bezoar in an Elderly Patient

International Journal of Gerontology, 2010
Small bowel obstruction caused by phytobezoars is quite uncommon in patients suffering from acute abdomen. The most common causes of small bowel obstruction are adhesive bands, incarcerated hernia, and adjacent tumor.
Ching-Hsueh Tseng, Chung-Chi Chen, Wen-Han Chang   +2 more
doaj   +1 more source

Clinical parameters as predictors of bacterial isolation in the uterine content of dogs suspected of pyometra [PDF]

, 2015
In this study, female canines referred with clinical signs consistent with pyometra were prospectively evaluated. Signalment, clinical signs, laboratory findings and surgical findings were compared between dogs with and without bacterial isolation based ...
Boyen, Filip, De Rooster, Hilde, Kitshoff, Adriaan, Polis, Ingeborgh, Tas, O, Van Goethem, Bart   +5 more
core   +1 more source

Metachronous Intraductal Papillary Neoplasm of the Bile Duct and Intraductal Papillary Mucinous Neoplasm of the Pancreas in a Patient Diagnosed With Mucinous Adenocarcinoma. [PDF]

, 2019
Intraductal papillary neoplasm of the bile duct (IPNB) is a rare biliary tumor, which shares some radiologic and histologic similarities with pancreatic intraductal papillary mucinous neoplasm (IPMN).
Brennan, Gregory T, Lee, John G
core   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source