Results 141 to 150 of about 268,703 (314)

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Aortic Dilatation in Children and Young People With ADPKD

Kidney International Reports
Introduction: Aortic root dilatation is a reported cardiovascular sequela seen in children and young people (CYP) with chronic kidney disease (CKD) but has yet to be described in those with autosomal dominant polycystic kidney disease (ADPKD).
Alexandra Savis, Emily Haseler, Hayley Beardsley, Phil J. Chowienczyk, John M. Simpson, Manish D. Sinha   +5 more
doaj   +1 more source

Idiopathic dilatation of pulmonary artery

, 2016
Idiopathic dilatation of pulmonary arteries (IDPA) is a rare abnormality of pulmonary arteries, the reported incidence in literature being as low as 0.007% in autopsy samples.
Shobhit Bansal, Deepak Talwar, Rahul Kumar Sharma, Sameer K Gupta   +3 more
core   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Flow-mediated dilatation facilitates transradial coronary angiography: a comparative study

Introduction: Radial artery (RA) spasm is demonstrated to be one of the most common complications of transradial approach (TRA). Aim: We hypothesised that radial flow-mediated dilation (FMD) can be used as a preprocedural method to assess the likelihood ...
Özge Özden, Medeni Karaduman, Enes Alıç, Emre özmen, Tuner, Haşim, Kaya, Yüksel, Rabia Çoldur, Haşim Tuner, ÜNLÜ, SERKAN, Aliç, Enes, Özmen, Emre, Karaduman, Medeni, Çoldur, Rabia, Bingol, Gülsüm, Öztürk, Fatih, Özden, Özge, Yüksel Kaya, Serkan Ünlü, Gülsüm Bingol, Fatih Öztürk   +19 more
core   +1 more source

Informative leaflet about neovaginal dilatation after MtF reassignment surgery: the importance of correct management of dilatation programme

, 2018
Objectives: To provide a valid guideline for an effective dilatation in MtF patients who underwent vaginal reconstructive surgery. Materials and Methods: Dilatation Informative Leaflet is composed by 5 parts: description of dilatators (with photos ...
Bucci, Stefano, Liguori, Giovanni, Di Grazia, M., Trombetta, Carlo, Rizzo, Michele, Migliozzi, Francesca   +5 more
core   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

A Novel Approach to Tracheostomal and Tracheal Stenosis: Dilatation Under Jet Ventilation with Inflated Foley Catheter—Two Cases

Surgical Techniques Development
Tracheostomal stenosis is a troublesome and distressing complication in laryngectomy. There are numerous techniques that describe dilatation of tracheostoma which are mostly performed under general anesthesia with the intermittent apnea technique.
Chia-Heng Chang, Sheng-Po Hao, Daniel Erick Amparado, Chung-Yu Hao   +3 more
doaj   +1 more source

Aortic dilatation in Marfan mice reduced by losartan.

, 2014
The aortic root dilatation rate was determined. Placebo-treated Marfan mice had a significantly higher dilatation rate compared to wildtype mice.
Stijntje Hibender (631852), Maarten Groenink (132181), Romy Franken (631851), Barbara J. M. Mulder (132187), Vivian de Waard (174124), Carlie J. M. de Vries (631854), Aeilko H. Zwinderman (93416), Teodora Radonic (132179), Alexander W. den Hartog (631853)   +8 more
core   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source