Results 61 to 70 of about 19,064 (180)
Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods
Chirality, Volume 38, Issue 7, July 2026.Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz +1 more
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 13, Page 5629-5662, 1 July 2026.Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite +9 more
wiley +1 more source
Diltiazem in hypertensive patients with type II diabetes mellitus
, 1988 Twenty-three patients with essential hypertension and diabetes mellitus type II were treated with the calcium antagonist diltiazem (120 to 180 mg twice daily). The mean dose was 307 mg/day.
Höglund, P +6 more
core +1 more source
Epidermal Patch Technologies for Integrated Healthcare and Infection Management
Advanced Healthcare Materials, Volume 15, Issue 24, 25 June 2026.Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang +7 more
wiley +1 more source
Fiber‐type soft bioelectronics for wearable and implantable sensing and therapy
BMEMat, Volume 4, Issue 2, June 2026.Fiber‐type soft bioelectronics are emerging as versatile platforms for wearable and implantable health monitoring and therapeutic applications. These bioelectronics use organic and inorganic matrices combined with advanced fillers, which feature high conductivity, electrochemical sensitivity, softness, and biocompatibility.
Haneul Kim +5 more
wiley +1 more source
, 1998 Objectives. This study was defined as a pilot investigation of the usefulness and safety of intravenous diltiazem as adjunctive therapy to tissue plasminogen activator in acute myocardial infarction, followed by oral therapy for 4 weeks.Background ...
Juneau, Martin +5 more
core +1 more source
A Case Report of PR Interval Prolongation Caused by Amlodipine
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Amlodipine is a widely used dihydropyridine calcium channel blocker. Its effects on the cardiac conduction system, especially PR interval prolongation, are rare but clinically important. We report a 25‐year‐old healthy male subject in a clinical trial with baseline first‐degree atrioventricular block (PR interval 230 ms).
Zhiying Fu +3 more
wiley +1 more source
Brazilian Journal of Pharmaceutical Sciences, 2013 The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not
Xi-Qing Yan +7 more
doaj
Anogenital Papular Mucinosis in Chronic Anal Fissures: A Review of a Reactive Mucinous Pattern
Dermatological Reviews, Volume 7, Issue 3, June 2026.ABSTRACT Background Anogenital papular mucinosis (APM) is a rare localized cutaneous mucinosis characterized by dermal mucin deposition presenting as flesh‐colored papules in the anogenital region. Its rarity and clinical resemblance to common infectious and inflammatory dermatoses contribute to frequent misdiagnosis.
Douglas Jaxon Vadner +5 more
wiley +1 more source
Magnesium and diltiazem relaxes phenylephrine-precontracted rat aortic rings
, 2012 Perioperative vasospasm during cardiovascular surgery is a challenging problem. Several vasodilator agents are frequently utilized for its prevention in surgical practice. Magnesium and diltiazem both have known potential vasorelaxant effects. We planned
Peker, Recep O. +3 more
core +1 more source