Results 151 to 160 of about 5,295 (204)

Toward a high-throughput in vitro model for estimating vitreous humor permeability of topically applied drugs. [PDF]

Sci Rep
Vincze A, Simon E, Koplányi G, Stankovits JG, Balogh-Weiser D, Gyarmati B, Nagy ZZ, Balogh GT.   +7 more
europepmc   +1 more source

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Selective spectrophotometric determination of diltiazem hydrochloride in tablets

Journal of Pharmaceutical and Biomedical Analysis, 1993
B V, Kamath, K, Shivram, A C, Shah
exaly   +3 more sources

A Simple and Rapid Analytical Method to Detect and Quantify the N‐Nitroso Desmethyl Diltiazem Impurity by Liquid Chromatography‐Tandem Mass Spectrometry in Diltiazem Hydrochloride

Separation Science Plus
ABSTRACT N‐nitroso desmethyl diltiazem is a known genotoxic impurity in the cardiovascular drug product diltiazem hydrochloride, raising significant concerns due to its potential carcinogenicity. Detection of such impurities at trace levels is crucial to ensure drug safety and regulatory compliance.
Manoj Kumar Mandapaka, Veeraswami Boddu
exaly   +2 more sources

Asymmetric syntheses of (+)-diltiazem hydrochloride

Journal of the Chemical Society, Chemical Communications, 1990
Efficient enantioselective syntheses of the important cardiac drug (+)-cis-(2S,3S)-diltiazem from (E)-methyl 4-methoxyphenylpropenoate via either the (2R,3S)- or (2S,3R)-enantiomers of threo-methyl 3-(4-methoxyphenyl)-2,3-dihydroxypropanoate are described.
Keith G. Watson, Yik M. Fung, Matthew Gredley, Graham J. Bird, W. Roy Jackson, Helen Gountzos, Barry R. Matthews   +6 more
openaire   +1 more source

Controlled release of diltiazem hydrochloride

Polymer International, 1995
AbstractA new type of complex reservoir–matrix system for the controlled delivery of diltiazen hydrochloride was developed. This capsule‐type device was designed for oral administration to humans and/or animals. It contained (i) an appropriate amount of the drug in a compartment; (ii) a swelling‐controlled membrane which was prepared by mixing ...
Ping Xu, James E. Mark, Song‐Bo Wang, Paul Nathan, Bernard Korol   +4 more
openaire   +1 more source

Diltiazem hydrochloride.

British journal of hospital medicine, 1995
Since their introduction in 1963, calcium-channel blockers, with their effectiveness and lack of side effects, have become widely used. Diltiazem hydrochloride, a benzothiazine, has its major role in the treatment of angina and is also used as an antihypertensive and antiarrhythmic.
D, Harrington, D J, Coltart
openaire   +1 more source

STABILITY OF DILTIAZEM HYDROCHLORIDE IN AQUEOUS SUGAR SOLUTIONS

Journal of Clinical Pharmacy and Therapeutics, 1988
The accelerated stability of diltiazem in aqueous sugar solutions, with or without sodium dihydrogen phosphate, was investigated using a high-pressure liquid chromatographic method. The degradation of diltiazem in all sugar solutions followed pseudo first-order kinetics.
M S, Suleiman, N M, Najib, M E, Abdelhameed   +2 more
openaire   +2 more sources

The Use of Diltiazem Hydrochloride in Cardiovascular Disorders

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1982
Diltiazem, a calcium channel blocking agent, has potent cardiovascular effects that are directly related to its influence on vascular smooth muscle, ventricular myocardium, and specialized conducting tissue. It causes coronary and peripheral vasodilation, has a negative chronotropic and dromotropic effect, and little to no negative inotropic effect in ...
B J, McAuley, J S, Schroeder
openaire   +2 more sources