Results 91 to 100 of about 4,393,923 (290)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Data Clustering via Dimension Reduction and Algorithm Aggregation
, 2008 We focus on the problem of clustering large textual data sets. We present 3 well-known clustering algorithms and suggest enhancements involving dimension reduction.
Race, Shaina L
core
Essential dimension of cubics [PDF]
, 2004 In this paper, we compute the essential dimension of the functor of cubics in three variables up to linear changes of coordinates when the base field has characteristic different from 2 and 3.
Giordano Favi +3 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
TOWARDS PCA DECOMPOSITION FOR THE WAVE-ATTRACTOR FLOWS
Cifra: Компьютерные науки и информатикаWave attractors, being particular hydrodynamical flows forming as a result of internal or inertial waves self-focusing, are rather complicated problem from the viewpoint of both computational fluid dynamics and visualizations due to the wave instability ...
Elistratov S.A.
doaj +1 more source
DIMENSION REDUCTION TRANSFORMATIONS IN DISCRIMINANT ANALYSIS [PDF]
Dimension reduction transformations in discriminant analysis are introduced. Their properties, as well as sufficient conditions for their characterization, are studied.
Santiago Velilla, Adolfo Hernández
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Functional Split of Zero-Forcing Based Massive MIMO for Fronthaul Load Reduction
IEEE Access, 2018 The evolution towards centralized radio access network (C-RAN) for 5G is driven by the need for improved network performance and reduced total-cost-of-ownership (TCO). In C-RAN, physically separated remote radio units (RRUs) and baseband units (BBUs) are
Yezi Huang +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source