Results 101 to 110 of about 9,586,369 (306)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Dimension reduction by random hyperplane tessellations

, 2013
Given a subset K of the unit Euclidean sphere, we estimate the minimal number m = m(K) of hyperplanes that generate a uniform tessellation of K, in the sense that the fraction of the hyperplanes separating any pair x, y in K is nearly proportional to the
Plan, Yaniv, Vershynin, Roman
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Dimension reduction in quantum sampling of stochastic processes

npj Quantum Information
Quantum technologies offer a promising route to the efficient sampling and analysis of stochastic processes, with potential applications across the sciences.
Chengran Yang, Marta Florido-Llinàs, Mile Gu, Thomas J. Elliott   +3 more
doaj   +1 more source

Determining Principal Component Cardinality through the Principle of Minimum Description Length

, 2019
PCA (Principal Component Analysis) and its variants areubiquitous techniques for matrix dimension reduction and reduced-dimensionlatent-factor extraction. One significant challenge in using PCA, is thechoice of the number of principal components.
A Blumer, AJ Donald, AP Dawid, AR Barron, C Eckart, DC Hoyle, IT Jolliffe, J Josse, J Rissanen, J Rissanen, J Rissanen, J Rissanen, JI Myung, M Mitzenmacher, M Zhu, MH Hansen, T Hastie, TM Cover, Y Choi   +18 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A Low-Complexity Joint TOAs and AOAs Parameter Estimator Using Dimension Reduction for FMCW Radar Systems

Elektronika ir Elektrotechnika, 2018
We propose a low-complexity of joint time delay of arrivals (TOAs) and angles of arrivals (AOAs) using dimension reduction for frequency modulated continuous-wave (FMCW) radar systems.
Sangdong Kim, Yeonghwan Ju, Jonghun Lee
doaj   +1 more source

Robust estimation of dimension reduction space [PDF]

Most dimension reduction methods based on nonparametric smoothing are highly sensitive to outliers and to data coming from heavy-tailed distributions. We show that the recently proposed methods by Xia et al.
Pavel Cizek, Wolfgang Härdle
core  

Dimension Reduction Methods [PDF]

, 2004
One characteristic of computational statistics is the processing of enormous amounts of data. It is now possible to analyze large amounts of highdimensional data through the use of high-performance contemporary computers.
Mizuta, Masahiro
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source