Results 121 to 130 of about 9,586,369 (306)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Multifeatures Fusion and Nonlinear Dimension Reduction for Intelligent Bearing Condition Monitoring

, 2016
Condition-based maintenance is critical to reduce the costs of maintenance and improve the production efficiency. Data-driven method based on neural network (NN) is one of the most used models for mechanical components condition recognition.
Liang Guo, Hongli Gao, HaiFeng Huang, He Xiang, Shichao Li   +4 more
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Goods Versus Characteristics: Dimension Reduction and Revealed Preference [PDF]

This paper compares the goods and characteristics models of the consumer within a non-parametric revealed preference framework. Of primary interest is to make a comparison on the basis of predictive success that takes into account dimension reduction ...
Matthew Polisson
core   +3 more sources

Effect of network structure on the accuracy of resilience dimension reduction

Frontiers in Physics
Dimension reduction is an effective method for system’s resilience analysis. In this paper, we investigate the effect of network structure on the accuracy of resilience dimension reduction.
Min Liu, Qiang Guo, Jianguo Liu
doaj   +1 more source

Sufficient Dimension Reduction via Distance Covariance

, 2016
We introduce a novel approach to sufficient dimension-reduction problems using distance covariance. Our method requires very mild conditions on the predictors.
Wenhui Sheng, Xiangrong Yin
semanticscholar   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Dimension Reduction Methods [PDF]

, 2011
One characteristic of computational statistics is the processing of enormous amounts of data. It is now possible to analyze large amounts of high-dimensional data through the use of high-performance contemporary computers. In general, however, several problems occur when the number of dimensions becomes high.
openaire   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Capturing fluctuations in multivariate intensive longitudinal data

Methods in Psychology
This paper introduces a novel method for intensive longitudinal data incorporating dimension reduction and time series analyses. The method capitalizes on the notion of determining distance or similarity parameters in the data.
Katerina M. Marcoulides, Hannah Hamling
doaj   +1 more source