Results 91 to 100 of about 1,603,370 (304)
Robust high-dimensional data analysis using a weight shrinkage rule [PDF]
, 2016 In high-dimensional settings, a penalized least squares approach may lose its efficiency in both estimation and variable selection due to the existence of either outliers or heteroscedasticity.
Luo, Bin +1 more
core
Robust three-dimensional best-path phase-unwrapping algorithm that avoids singularity loops [PDF]
, 2009 In this paper we propose a novel hybrid three-dimensional phase-unwrapping algorithm, which we refer to here as the three-dimensional best-path avoiding singularity loops (3DBPASL) algorithm.
Burton, David +8 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Scaling the Response of a Simplified Hull Girder Subjected to Underwater Explosions
Engineering ProceedingsUnderwater explosions (UNDEXs) represent a significant threat to marine vessels, motivating the analysis of their resulting dynamic response and damage. Conducting experimental investigations on full-scale ships, while being the most consistent strategy,
Giovanni Marchesi +3 more
doaj +1 more source
Improving neural network models of physical systems through dimensional analysis
, 2003 The paper presents a technique for generating concise neural network models of physical systems. The neural network models are generated through a two-stage process.
T. Degroff, D. Gunaratnam, J.S. Gero
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
MODELING OF ONE DIMENSIONAL FLOW OVER SEMICIRCLE CRESTED WEIR PROFILE USING (HEC-RAS) PROGRAM
Diyala Journal of Engineering Sciences, 2017 A semicircle crest profile extending across full width of laboratory channel (suppressed) provides measurements of discharge – head under free flow condition.
Thabet mohammed abdulatif
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2012 The unsteady three-dimensional flow of couple stress fluid over a stretched surface is investigated. Analysis has been performed in the presence of mass transfer and chemical reaction. Nonlinear flow analysis is computed by a homotopic approach.
Safdar, Ambreen +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source