Results 71 to 80 of about 25,927,166 (251)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Establishing Long Term Seepage Behavior of Zoned Embankment Dams with Three-Dimensional Seepage Analysis [Elektronisk resurs]

, 2009
Since seepage-related problems are the main cause of morethan fourty percent of dam failures, seepage analysis is oneof the most important stages in the design process of anembankment dam.
Jafarzadeh, Fardin,, Ferdos, Farzad,
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

A short geostatistical study of the three-dimensional spatial structure of fumonisins in stored maize [PDF]

, 2010
The heterogeneous three-dimensional spatial distribution of mycotoxins has proven to be one of the main limitations for the design of effective sampling protocols.
N. Magan, M. Rivas Casado, D. Parsons, P. Battilani, A. Pietri, Battilani, Paola, Rivas Casado, Monica, Pietri, A., Magan, Naresh, Weightman, R. M., Pietri, Amedeo, R. Weightman, Parsons, David J.   +12 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Scaling the Response of a Simplified Hull Girder Subjected to Underwater Explosions

Engineering Proceedings
Underwater explosions (UNDEXs) represent a significant threat to marine vessels, motivating the analysis of their resulting dynamic response and damage. Conducting experimental investigations on full-scale ships, while being the most consistent strategy,
Giovanni Marchesi, Luca Lomazzi, Marco Giglio, Andrea Manes   +3 more
doaj   +1 more source

Spatial 3D Matérn Priors for Fast Whole-Brain fMRI Analysis

, 2021
Bayesian whole-brain functional magnetic resonance imaging (fMRI) analysis with three-dimensional spatial smoothing priors has been shown to produce state-of-the-art activity maps without pre-smoothing the data.
Lindgren, Finn,, Bolin, David, Eklund, Anders,, Bolin, David,, Sidén, Per, Eklund, Anders, Villani, Mattias, Sidén, Per,, Lindgren, Finn, Villani, Mattias,, David Bolin, Finn Lindgren, Mattias Villani, Per Sidén, Anders Eklund   +14 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source