Results 61 to 70 of about 1,603,370 (304)

Analysis of Strength Effects on the Dynamic Response of a Shaped-Charge Under Lateral Disturbances

Applied Sciences
To study the variation law of the penetration power of energy-concentrated jets on target plates with different yield strengths under lateral disturbance, a finite element model of the dynamic penetration of energy-concentrated jets was established ...
Xuepeng Zhang, Can Xu, Jianya Yi, Xudong Li, Jianping Yin   +4 more
doaj   +1 more source

Spatial 3D Matérn Priors for Fast Whole-Brain fMRI Analysis

, 2021
Bayesian whole-brain functional magnetic resonance imaging (fMRI) analysis with three-dimensional spatial smoothing priors has been shown to produce state-of-the-art activity maps without pre-smoothing the data.
Lindgren, Finn,, Bolin, David, Eklund, Anders,, Bolin, David,, Sidén, Per, Eklund, Anders, Villani, Mattias, Sidén, Per,, Lindgren, Finn, Villani, Mattias,   +9 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Scale-Agnostic Models Based on Dimensionless Quality by Design as Pharmaceutical Development Accelerator

Pharmaceuticals
This comprehensive review of the synergistic use of Quality by Design (QbD) and the Pi–Buckingham theorem explores an innovative approach to enhancing product development and process optimization within the pharmaceutical industry.
Miquel Romero-Obon, Virginia Sancho-Ochoa, Khadija Rouaz-El-Hajoui, Pilar Pérez-Lozano, Marc Suñé-Pou, Josep María Suñé-Negre, Encarna García-Montoya   +6 more
doaj   +1 more source

Dimensional response analysis of bilinear systems subjected to non-pulselike earthquake ground motions [PDF]

, 2011
The maximum inelastic response of bilinear single-degree-of-freedom systems when subjected to ground motions without distinguishable pulses is revisited with dimensional analysis by identifying time scales and length scales in the time histories of ...
Karavasilis, Theodore L., Seo, C-Y., Nicos Makris, Makris, Nicos, Makris, N., Choung-Yeol Seo, Theodore L. Karavasilis, Seo, Choung-Yeol, Karavasilis, T.L.   +8 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Experimental Research on Hydraulic Collecting Spherical Particles in Deep Sea Mining

Energies, 2018
Hydraulic collecting is the key technology in deep sea mining and dredging engineering. It determines economic benefits of the project and environmental issues. However, mechanistic studies of hydraulic collecting are rarely described. In this study, the
Guocheng Zhao, Longfei Xiao, Tao Peng, Mingyuan Zhang   +3 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source