Results 51 to 60 of about 25,927,166 (251)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Combine Dimensional Analysis with Educated Guessing
, 2018 peer reviewedUse dimensional analysis and educated guessing to simplify experimentation and simulation, gain physical insight from empirical relationships, and extrapolate ...
Gilet, Tristan, Gommes, Cédric
core +1 more source
Analysis of Strength Effects on the Dynamic Response of a Shaped-Charge Under Lateral Disturbances
Applied SciencesTo study the variation law of the penetration power of energy-concentrated jets on target plates with different yield strengths under lateral disturbance, a finite element model of the dynamic penetration of energy-concentrated jets was established ...
Xuepeng Zhang +4 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
PharmaceuticalsThis comprehensive review of the synergistic use of Quality by Design (QbD) and the Pi–Buckingham theorem explores an innovative approach to enhancing product development and process optimization within the pharmaceutical industry.
Miquel Romero-Obon +6 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2020 The stability of a tunnel face is described by the combined effects of surcharge load, self-weight of the soil, and internal supporting pressure. This combination can cause failure in either blowout or collapse.
Shiau, Jim, Al-Asadi, Fadhil
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Experimental Research on Hydraulic Collecting Spherical Particles in Deep Sea Mining
Energies, 2018 Hydraulic collecting is the key technology in deep sea mining and dredging engineering. It determines economic benefits of the project and environmental issues. However, mechanistic studies of hydraulic collecting are rarely described. In this study, the
Guocheng Zhao +3 more
doaj +1 more source