Results 41 to 50 of about 1,603,370 (304)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Exploring the transformation of chemical components and the discovery of anti-tumor active components in the fruit of Sinopodophyllum hexandrum

Frontiers in Nutrition
IntroductionThe fruit of Sinopodophyllum hexandrum (FSH) is derived from Sinopodophyllum hexandrum (Royle) Ying, a plant belonging to the family Berberidaceae of the order Ranunculaceae.
Xiang-mu Tian, Shuai Wang, Shuai Wang, Shuai Wang, Shuai Wang, Tian-jiao Li, Tian-jiao Li, Tian-jiao Li, Xin-xin Yang, Xin-xin Yang, Xin-xin Yang, Xin-xin Yang, Yong-rui Bao, Yong-rui Bao, Yong-rui Bao, Yong-rui Bao, Xian-sheng Meng, Xian-sheng Meng, Xian-sheng Meng   +18 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Enhancement of content, purity and anti-myocardial ischemia–reperfusion injury activity of persimmon leaf flavonoids: Ultrasonic-assisted extraction, purification and related mechanism

Ultrasonics Sonochemistry
Persimmon leaves (PL) are agricultural and forestry by-products rich in flavonoids with diverse pharmacological activities. To fully exploit their medicinal value, we established an optimized integrated process combining ultrasound-assisted extraction ...
Liying Han, Qiang Zhang, Jinnan Huo, Chenxiao Guo, Shuai Wang, Yongrui Bao, Tianjiao Li, Yi Zheng, Yanqiu Li, Bing Wang, Xiansheng Meng   +10 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Modeling of Tunneling Total Loads Based on Symbolic Regression Algorithm

Applied Sciences, 2021
The tunneling total load is one of the core control parameters for safe and efficient construction using tunneling machines. However, because the tunneling process involves complex coupling relationships between the equipment and the local geology ...
Liting Zhang, Qian Zhang, Siyang Zhou, Shanglin Liu   +3 more
doaj   +1 more source

Two types of limit cycles of a resonant converter modelled by a three-dimensional system

, 2008
In this paper, the long-run dynamics of a controlled resonant converter, modelled as a piecewise system, is studied. The modelling of the resonant converter can be done using various approximations and the long-run dynamics of the two dimensional ...
Hultgren, Anders,, Lindström, Torsten,, Melin, Jan,, Lindström, Torsten, Melin, Jan, Hultgren, Anders   +5 more
core   +1 more source