Results 161 to 170 of about 9,957,911 (333)

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin   +12 more
wiley   +1 more source

A door to model reduction in high-dimensional parameter space

open access: hybrid, 2018
Charles Paillet   +2 more
openalex   +1 more source

A Probabilistic Graph Coupling View of Dimension Reduction [PDF]

open access: green, 2022
Hugues Van Assel   +3 more
openalex   +1 more source

INF2‐Related Charcot–Marie–Tooth Disease in a Japanese Cohort: Genetic and Clinical Insights

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background INF2 mutations cause focal segmental glomerulosclerosis (FSGS) and Charcot–Marie–Tooth disease (CMT). Accurate genetic diagnosis is critical, as INF2‐related FSGS is typically resistant to immunotherapy yet rarely recurs after transplantation, and its associated neuropathy can mimic treatable immune‐mediated disorders such as ...
Chikashi Yano   +27 more
wiley   +1 more source

Annual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich   +10 more
wiley   +1 more source

Predictive analysis of total organic carbon (TOC) in shale targets: example from the Lower Cretaceous of the Austral Basin (Patagonia, Argentina) using machine learning on outcrop data

open access: yesLatin American Journal of Sedimentology and Basin Analysis
The Río Mayer Formation (Lower Cretaceous) of the Austral Basin, Patagonia, is a key source rock for unconventional reservoirs. This study explores the potential of machine learning (ML) for predicting Total Organic Carbon (TOC) content using outcrop ...
Sebastian M. Richiano, Federico Ares
doaj  

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