Results 91 to 100 of about 4,596,502 (304)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

SIMULATION-BASED ANALYSIS FOR OPTIMIZING MOLD DESIGN OF PLASTIC HARDNESS TEST SPECIMENS USING KEY PARAMETERS

Rekayasa Mesin
This study aims to compare the performance of two injection molding designs—Design A and Design B—for producing plastic hardness test specimens. Design A showed a fill time of 1.03 s and cooling quality covering 84.2% of the part, compared to 1.06 s and ...
Nur Fitria Pujo Leksonowati, Nurman Pamungkas, Meilani Manurung, Adhe Aryswan, Rahman Hakim, Windy Stefani, Adi Purba, Kholillurrahman Khollilurrahman, Ninda Batubara   +8 more
doaj   +1 more source

Use of Eucalyptus grandis clones treated with a water repellent to improve the dimensional stability of utility poles

Maderas: Ciencia y Tecnología, 2021
Wood is a common construction material used in most environments. However, its sensibility to abiotic agents, in particular those that affect the dimensional stability, limits the materials durability and decreases its properties.
Claudia Ibañez, Damian Gherscovic
doaj  

Comparison of Dimensional Stability and Surface Detail Reproduction of Silicone Based Impression Materials

Journal of Nobel Medical College, 2013
Journal of Nobel Medical College Vol.
Riwaj Karki, Dipendra Naulakha
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Patterning Behavior of RAFT-Derived 3-Arm Star Terpolymers

Journal of Manufacturing and Materials Processing
The uniformity of polymer matrices can strongly influence pattern retention during negative-tone development. In this study, two 3-arm star terpolymers, designated HTM Random and HTM Block, were synthesized via reversible addition–fragmentation chain ...
Yura Choi, Jinyoung Kim, Namchul Cho
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Properties of Cross-laminated Oriented Bamboo Scrimber Board (CL-OBSB)

BioResources, 2022
Physical and mechanical properties were evaluated for cross-laminated oriented bamboo scrimber board (CL-OBSB). Results of non-destructive testing revealed a linear relationship of parallel grain content with ultrasonic-wave velocity, dynamic modulus of ...
Min-Jay Chung, Sheng-Yang Wang
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source