Results 111 to 120 of about 1,739,210 (295)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
BioResourcesFurfurylation expands the value of wood and wood-based products in construction and engineering applications by improving its dimensional stability and lowering its moisture absorption.
Minghui Liu +3 more
doaj
Drvna Industrija, 2016 Three layer particleboards were manufactured using hygrothermally treated and untreated Laureliopsis philippiana (tepa) particles with urea-formaldehyde (UF) resin.
Rommel Crespo Gutiérrez +2 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Applied SciencesThe aim of the study was to investigate the effect of hydrothermal treatment (different steaming process) conditions, specifically temperature, pressure, and steaming time on selected physical properties of beech wood (Fagus sylvatica L.), such as ...
Ivan Klement +3 more
doaj +1 more source
Stability in a two-dimensional combustion model
Interfaces and Free Boundaries, Mathematical Analysis, Computation and Applications, 2004 Summary: We study the stability of a planar travelling wave in the two-dimensional nearly equidiffusional flame combustion model when the reduced Lewis number is equal to zero. The functional analytic setting consists of spaces of suitably exponentially weighted Hölder continuous functions.
HULSHOF J +1 more
openaire +4 more sources
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Fibers, 2019 Seed meal of three trees common to the Midwest region of the USA (Honey locust, Gleditsia triacanthos L., family Fabaceae), Osage orange (Maclura pomifera (Raf.) Schneid., family Moraceae) and Black locust (Robinia pseudoacacia L., family Fabaceae) were ...
Brent Tisserat, Rogers Harry-O’kuru
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Rekayasa MesinThis study aims to compare the performance of two injection molding designs—Design A and Design B—for producing plastic hardness test specimens. Design A showed a fill time of 1.03 s and cooling quality covering 84.2% of the part, compared to 1.06 s and ...
Nur Fitria Pujo Leksonowati +8 more
doaj +1 more source