Results 91 to 100 of about 4,992,572 (251)

Low Bandgap Donor-Acceptor π-Conjugated Polymers From Diarylcyclopentadienone-Fused Naphthalimides

open access: yesFrontiers in Chemistry, 2019
Two novel aromatic imides, diarylcyclopentadienone-fused naphthalimides (BCPONI-2Br and TCPONI-2Br), are designed and synthesized by condensation coupling cyclopentadienone derivatives at the lateral position of naphthalimide skeleton.
Xiaolin Li   +9 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

A Novel Single-Loop Mechanism for Neck Rehabilitation

open access: yesBiomimetics
Trauma, amyotrophic lateral sclerosis (ALS), and head and neck cancer (HNC), which cause neck pain, are only some of the possible issues requiring suitable therapy for alleviating or even healing the neck dysfunctions they cause.
Raffaele Di Gregorio
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

open access: yesFEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito   +7 more
wiley   +1 more source

A Preliminary Design of a Novel Limb Mechanism for a Wheel–Legged Robot

open access: yesApplied Sciences
This paper presents a new approach to the dimensional synthesis of a robotic limb mechanism for a wheel-legged robot. The proposed kinematic structure enables independent control of wheel motions relative to the robot platform, allowing each drive to ...
Przemysław Sperzyński
doaj   +1 more source

Two-dimensional manganese oxide on ceria for the catalytic partial oxidation of hydrocarbons

open access: yes, 2022
Although the rational synthesis of catalysts with strong oxide-support interactions to modulate the geometric and electronic structures and achieve unusual catalytic performance is challenging in heterogeneous catalysis, it is in significant demand for ...
Luo, Qingsong   +7 more
core  

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

open access: yesFEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Synthesis of Spatial Linkage with 5 Positions Based on Kinematic Geometry Characteristics

open access: yes工程科学与技术
A classic problem in mechanism design is the dimensional synthesis of mechanisms, and established here is a relatively systematic, transparent, and simple geometric process for the dimensional synthesis of spatial linkages.
Hanchao WANG   +3 more
doaj  

Dimensional Synthesis and Optimization of Leading and Mixed-Leading Double Four-Bar Steering Mechanisms: A Comparative Metaheuristic Approach

open access: yesMachines
This study investigates the dimensional synthesis and optimization of multi-link steering mechanisms—namely, the leading and mixed-leading double four-bar configurations—for front-wheel-drive vehicles. To overcome the accuracy limitations of conventional
Yaw-Hong Kang, Da-Chen Pang
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

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