Results 31 to 40 of about 379,758 (236)

Spectral dimensionality reduction for HMMs [PDF]

open access: yes, 2012
Hidden Markov Models (HMMs) can be accurately approximated using co-occurrence frequencies of pairs and triples of observations by using a fast spectral method in contrast to the usual slow methods like EM or Gibbs sampling.
Foster, Dean P.   +2 more
core   +2 more sources

Dimensionality reduction in translational noninvariant wave guides

open access: yes, 2008
A scheme to reduce translational noninvariant quasi-one-dimensional wave guides into singly or multiply connected one-dimensional (1D) lines is proposed.
Aeberhand   +23 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel   +3 more
wiley   +1 more source

Accuracy, robustness and scalability of dimensionality reduction methods for single-cell RNA-seq analysis

open access: yesGenome Biology, 2019
Background Dimensionality reduction is an indispensable analytic component for many areas of single-cell RNA sequencing (scRNA-seq) data analysis. Proper dimensionality reduction can allow for effective noise removal and facilitate many downstream ...
Shiquan Sun   +3 more
doaj   +1 more source

Overlap Removal of Dimensionality Reduction Scatterplot Layouts

open access: yes, 2021
Dimensionality Reduction (DR) scatterplot layouts have become a ubiquitous visualization tool for analyzing multidimensional data items with presence in different areas.
Eler, Danilo M.   +4 more
core  

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Linguistic Geometries for Unsupervised Dimensionality Reduction [PDF]

open access: yes, 2010
Text documents are complex high dimensional objects. To effectively visualize such data it is important to reduce its dimensionality and visualize the low dimensional embedding as a 2-D or 3-D scatter plot.
Balasubramanian, Krishnakumar   +2 more
core  

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Nonlinear dimensionality reduction in climate data [PDF]

open access: yesNonlinear Processes in Geophysics, 2004
Linear methods of dimensionality reduction are useful tools for handling and interpreting high dimensional data. However, the cumulative variance explained by each of the subspaces in which the data space is decomposed may show a slow convergence that ...
A. J. Gámez   +3 more
doaj  

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