Results 261 to 270 of about 197,285 (307)
The impact of physiological oxidants on triggering amyloid formation of the cell cycle regulator protein p16<sup>INK4A</sup>. [PDF]
Protein SciSmith BR +6 more
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Breaking the bonds: targeting protein dimerization for prostate cancer therapy. [PDF]
EndocrinologySingh N, Heemers HV.
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MET Dependence Oversteps EGFR Dependence via Balancing Dimerization of the Receptor Tyrosine Kinases in Osimertinib-Resistant MET-Amplified, EGFR-Mutated Non-Small Cell Lung Cancer. [PDF]
Thorac CancerYagami Y +9 more
europepmc +1 more source
Langerhans cell histiocytosis: molecular mechanisms underlying pathogenesis and emerging targeted therapeutics. [PDF]
Cancer Metastasis RevLi Q, Hu J.
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Journal of Molecular Spectroscopy, 1999
Spectra of the symmetric nu1 vibration of the NO dimer have been recorded in gas phase at low temperature, with a high-resolution infrared Fourier transform spectrometer. All the lines were least-squares fitted to a Voigt profile convoluted with the well-known apparatus function of the spectrometer. By means of this method, the frequencies of more than
, Dkhissi, , Lacome, , Perrin
openaire +2 more sources
Spectra of the symmetric nu1 vibration of the NO dimer have been recorded in gas phase at low temperature, with a high-resolution infrared Fourier transform spectrometer. All the lines were least-squares fitted to a Voigt profile convoluted with the well-known apparatus function of the spectrometer. By means of this method, the frequencies of more than
, Dkhissi, , Lacome, , Perrin
openaire +2 more sources
Current Medicinal Chemistry, 2022
Abstract: This review intends to summarize the structures of an extensive number of symmetrical-dimeric drugs, having two monomers, linked via a bridging entity emphasizing the versatility of biologically active substances reported to possess dimeric structures.
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Abstract: This review intends to summarize the structures of an extensive number of symmetrical-dimeric drugs, having two monomers, linked via a bridging entity emphasizing the versatility of biologically active substances reported to possess dimeric structures.
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Chemistry – A European Journal, 2019
AbstractBinaphthyl‐3,3′,4,4′‐tetraone was prepared and coupled to different bis(TIPS‐ethynyl)‐substituted (TIPS=triisopropyl silane) aromatic diamines, resulting in the formation of dimeric benzo‐fused azaacenes, centrally connected by a single bond.
Sebastian Hahn +9 more
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AbstractBinaphthyl‐3,3′,4,4′‐tetraone was prepared and coupled to different bis(TIPS‐ethynyl)‐substituted (TIPS=triisopropyl silane) aromatic diamines, resulting in the formation of dimeric benzo‐fused azaacenes, centrally connected by a single bond.
Sebastian Hahn +9 more
openaire +2 more sources
Dimerization mechanisms of heterocyclic carbenes
Journal of Physical Organic Chemistry, 2005 The dimerization reactions of a series of heterocyclic carbenes based on the 1,3-dimethylimidazol-2-ylidene template were studied extensively using molecular orbital calculations.
Brian Yates
exaly +1 more source
2016
It is widely accepted that a large number of proteins that are responsible for cellular function exist as dimers or need to be activated by dimerization before mediating certain signaling pathways. Simultaneously targeting both monomeric moieties of the dimeric proteins has shown potential in the development of various therapeutic agents.
Shang-Gao, Liao, Jian-Min, Yue
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It is widely accepted that a large number of proteins that are responsible for cellular function exist as dimers or need to be activated by dimerization before mediating certain signaling pathways. Simultaneously targeting both monomeric moieties of the dimeric proteins has shown potential in the development of various therapeutic agents.
Shang-Gao, Liao, Jian-Min, Yue
openaire +2 more sources