Results 251 to 260 of about 197,285 (307)

From Berzelius to Hyperspace: Previously Unrecognized Network of Reactivity in Textbook Brominations

Angewandte Chemie, EarlyView.
Robotic scans across multidimensional condition spaces of classic bromination reactions uncover regions of previously unrecognized reactivity, yielding new major products and novel substitution patterns. Correlation and anticorrelation analyses of product distributions across these hyperspaces enable reconstruction of the underlying mechanistic ...
Yankai Jia, Wai‐Shing Wong, Yasemin Bilgi‐Gadina, Louis P. J.‐L. Gadina, King‐Lam Kwong, Yanqiu Jiang, Nikolaos Vagkidis, Benito Marazzi, Peter R. Schreiner, Bartosz A. Grzybowski   +9 more
wiley   +1 more source

Epidermal growth factor receptor as a target enzyme in cancer therapy: Structural and functional insights from crystallography. [PDF]

Indian J Pharmacol
Magar VK, Khavane K, Wagh A, Shelke S, Padul R, Dudhane S.   +5 more
europepmc   +1 more source

Dialkyl Ethers and Sacrificial Zinc: Oxide Synthons for Calcium tert‐Butoxide Formation

Angewandte Chemie, EarlyView.
When treated with dialkyl ethers, [(BDI)Ca‐μ‐H‐Zn(t‐Bu)2(η6‐C7H8)] (BDI = HC{C(Me)NDipp}2 initiates a sequence of twofold ether dealkylation and oxide sequestration as tert‐butoxide in a process predicated on a combination of extreme basicity and a cooperative redox process administered by the dissimilar constituent metals. (Generative AI (ChatGPT) was
Kyle G. Pearce, Agustín Morales, Michael S. Hill, Claire L. McMullin   +3 more
wiley   +1 more source

Integrative structural and dynamics studies of epidermal growth factor receptor (EGFR). [PDF]

Exp Mol Med
Yoon J, Lee SH, Moon S, Gebremedhn H, Gebregiworgis T, Lee KY.   +5 more
europepmc   +1 more source

Modular Access to α‐Tertiary Amines: Electrochemical Tandem Di‐Functionalization of Olefins With Ammonia Surrogates and Amino Acids

Angewandte Chemie, EarlyView.
A metal‐ and oxidant‐free electrochemical multicomponent di‐functionalization strategy that rapidly converts 1,1‐disubstituted alkenes into α‐tertiary primary amines with simultaneous installation of bio‐relevant sulfur or selenium motifs was devised for late‐stage functionalization. ABSTRACT Quaternary carbon centers, especially those bearing nitrogen,
Adrija Ghosh, Tarun, Sven Erik Peters, Lutz Ackermann, Debasis Banerjee   +4 more
wiley   +1 more source

Adenoviral E3/49K: CD45-targeted immune evasion and therapeutic potential. [PDF]

Front Cell Infect Microbiol
Windheim M, Aichane-Simon K.
europepmc   +1 more source

Taming a Blue Gas—Structure and Chemistry of Hexafluorothioacetone

Angewandte Chemie International Edition, EarlyView.
Hexafluorothioacetone (1), a blue gas at r.t., was synthesized by flash vacuum pyrolysis of its cyclic dimer at 660°C. We discuss fundamental properties of elusive 1, including single‐crystal structure and nuclear magnetic resonance spectroscopy, despite its tendency to dimerize even at –74°C.
Hennes Günther, Antti J. Karttunen, Xiulan Xie, Frank Tambornino   +3 more
wiley   +1 more source

Novel Eukaryotic Double Histone Fold Motifs Sharing High Sequence Identity with Histones H3 and H4 in Single-Domain Proteins and in Proteins Featuring Remarkable Histone Fold Multiplets. [PDF]

ACS Omega
Ranaudo A, Miyake T, Shehi H, Cosentino U, Orlando M, Nardini M, Greco C.   +6 more
europepmc   +1 more source

Kinetics, thermodynamics, and mechanisms of PMO interactions from computational molecular modeling. [PDF]

Mol Ther Nucleic Acids
Chou Y, Novikov I, Pierson D, Marx KA, Chanda A, Barsegov V.   +5 more
europepmc   +1 more source

Cis glycan-glycan interactions organize membrane nanodomains that tune receptor signaling. [PDF]

Nat Commun
Suzuki KGN, Komura N, Asano S, Takahashi M, Yamaguchi E, Yamazaki A, Imamura A, Shibutani S, Chadda R, Tsunoyama TA, Fujiwara TK, Hirosawa KM, Morigaki K, Furukawa K, Furukawa K, Yamauchi Y, Kitamura Y, Nagaoka M, Ando H, Kusumi A.   +19 more
europepmc   +1 more source