Results 1 to 10 of about 28,189 (202)
Effects of dimethyl fumarate on neuroprotection and immunomodulation [PDF]
Journal of Neuroinflammation, 2012 Background Neuronal degeneration in multiple sclerosis has been linked to oxidative stress. Dimethyl fumarate is a promising novel oral therapeutic option shown to reduce disease activity and progression in patients with relapsing-remitting multiple ...
Albrecht Philipp +14 more
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Dimethyl Fumarate vs. Monomethyl Fumarate: Unresolved Pharmacologic Issues [PDF]
PharmaceuticsDimethyl fumarate (DMF) has established a significant position among therapies for multiple sclerosis and psoriasis and is now being investigated for repurposing to many other non-malignant diseases.
Jana Kopincova, Iveta Bernatova
doaj +2 more sources
Hepato‐Renal Protective Potential of Dimethyl Fumarate in Alloxan‐Induced Diabetic Mice Model by Modulating of Sirt1, Nrf2 and Inflammatory Genes Expressions [PDF]
Endocrinology, Diabetes & MetabolismAim Despite advances in diabetes treatments, the effects of this disease have not yet been adequately reversed or prevented in patients. Therefore, development of more effective medication‐assisted treatments in this field is needed.
Parisa Saberi‐Hasanabadi +5 more
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Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme. [PDF]
PLoS ONE, 2014 Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic acid in a trans conformation around the carbon-carbon
Ju-Yi Hsieh +5 more
doaj +5 more sources
Evaluation of the effects of dimethyl fumarate on transforming growth factor beta levels in the liver of rats with bile duct ligation-induced cholestasis [PDF]
Toxicology ReportsBackground: Cholestasis is a reduction or cessation of bile flow in the biliary system, which can be life-threatening. Dimethyl Fumarate could induce anti-inflammatory and antioxidant effects in the body.
Hannaneh Vossoughi +3 more
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Transcriptome Analysis of Dimethyl Fumarate Inhibiting the Growth of Aspergillus carbonarius [PDF]
ToxinsAspergillus carbonarius is one of the main pathogens responsible for postharvest diseases in fruits and is also one of the main ochratoxin A-producing strains. It not only causes significant economic losses but also poses a risk to human health. We found
Siruo Wang +6 more
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Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases [PDF]
Nature Communications, 2018 Dimethyl fumarate (DMF) is a major drug in the treatment of psoriasis and multiple sclerosis. Here the authors reveal a mechanism of RSK/MSK inhibition through covalent inhibition that can explain the observed clinical effects and the dose–response ...
Jacob Lauwring Andersen +10 more
doaj +4 more sources
Reactions Weekly, 2017 Background: Delayed-release dimethyl fumarate (DMF; also known as gastroresistant DMF) is indicated for the treatment of relapsing multiple sclerosis. Flushing and gastrointestinal (GI) adverse events (AEs) are common within the first few months of starting DMF therapy.
Robert J. Fox +2 more
+6 more sources
Hospital Pharmacy, 2013 Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing
Cada, Dennis J +2 more
openaire +3 more sources
Communications Biology, 2023 Dimethyl fumarate is an ester from the Krebs cycle intermediate fumarate. This drug is approved and currently used for the treatment of psoriasis and multiple sclerosis, and its anti-angiogenic activity was reported some years ago.
Mª Carmen Ocaña +11 more
doaj +1 more source