Results 1 to 10 of about 30,023 (217)

Effects of dimethyl fumarate on neuroprotection and immunomodulation [PDF]

Journal of Neuroinflammation, 2012
Background Neuronal degeneration in multiple sclerosis has been linked to oxidative stress. Dimethyl fumarate is a promising novel oral therapeutic option shown to reduce disease activity and progression in patients with relapsing-remitting multiple ...
Albrecht Philipp, Bouchachia Imane, Goebels Norbert, Henke Nadine, Hofstetter Harald H, Issberner Andrea, Kovacs Zsuzsa, Lewerenz Jan, Lisak Dmitrij, Maher Pamela, Mausberg Anne-Kathrin, Quasthoff Kim, Zimmermann Corinna, Hartung Hans-Peter, Methner Axel   +14 more
doaj   +2 more sources

Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme. [PDF]

PLoS ONE, 2014
Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic acid in a trans conformation around the carbon-carbon
Ju-Yi Hsieh, Jyung-Hurng Liu, Pai-Chun Yang, Chi-Li Lin, Guang-Yaw Liu, Hui-Chih Hung   +5 more
doaj   +11 more sources

Dimethyl Fumarate vs. Monomethyl Fumarate: Unresolved Pharmacologic Issues [PDF]

Pharmaceutics
Dimethyl fumarate (DMF) has established a significant position among therapies for multiple sclerosis and psoriasis and is now being investigated for repurposing to many other non-malignant diseases.
Jana Kopincova, Iveta Bernatova
doaj   +2 more sources

Transcriptome Analysis of Dimethyl Fumarate Inhibiting the Growth of Aspergillus carbonarius [PDF]

Toxins
Aspergillus carbonarius is one of the main pathogens responsible for postharvest diseases in fruits and is also one of the main ochratoxin A-producing strains. It not only causes significant economic losses but also poses a risk to human health. We found
Siruo Wang, Bowen Tai, Xifan Yu, Erfeng Li, Gang Wang, Jing Jin, Fuguo Xing   +6 more
doaj   +2 more sources

Evaluation of the effects of dimethyl fumarate on transforming growth factor beta levels in the liver of rats with bile duct ligation-induced cholestasis [PDF]

Toxicology Reports
Background: Cholestasis is a reduction or cessation of bile flow in the biliary system, which can be life-threatening. Dimethyl Fumarate could induce anti-inflammatory and antioxidant effects in the body.
Hannaneh Vossoughi, Pejman Mortazavi, Mahsa Ale-Ebrahim, Razieh Hosseini   +3 more
doaj   +2 more sources

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases [PDF]

Nature Communications, 2018
Dimethyl fumarate (DMF) is a major drug in the treatment of psoriasis and multiple sclerosis. Here the authors reveal a mechanism of RSK/MSK inhibition through covalent inhibition that can explain the observed clinical effects and the dose–response ...
Jacob Lauwring Andersen, Borbala Gesser, Erik Daa Funder, Christine Juul Fælled Nielsen, Helle Gotfred-Rasmussen, Mads Kirchheiner Rasmussen, Rachel Toth, Kurt Vesterager Gothelf, J. Simon C. Arthur, Lars Iversen, Poul Nissen   +10 more
doaj   +4 more sources

The crystal structures of methyl prop-2-ynoate, dimethyl fumarate and their protonated species. [PDF]

Acta Crystallogr C Struct Chem
Hollenwäger D, Bockmair V, Kornath AJ.
europepmc   +3 more sources

Dimethyl Fumarate Treatment for Psoriasis in Real-World Clinical Practice: An Analysis from the Swiss Registry.

Dermatology
Maul LV, Ak M, Cerminara SE, Simic D, Gössinger EV, Roider E, Darzina A, Zink A, Oyanguren Monferrer I, Oestereich F, Mateu E, Navarini AA, Kündig T, Maul JT.   +13 more
europepmc   +2 more sources

New insights in the targets of action of dimethyl fumarate in endothelial cells: effects on energetic metabolism and serine synthesis in vitro and in vivo

Communications Biology, 2023
Dimethyl fumarate is an ester from the Krebs cycle intermediate fumarate. This drug is approved and currently used for the treatment of psoriasis and multiple sclerosis, and its anti-angiogenic activity was reported some years ago.
Mª Carmen Ocaña, Manuel Bernal, Chendong Yang, Carlos Caro, Alejandro Domínguez, Hieu S. Vu, Casimiro Cárdenas, María Luisa García-Martín, Ralph J. DeBerardinis, Ana R. Quesada, Beatriz Martínez-Poveda, Miguel Ángel Medina   +11 more
doaj   +1 more source

New and Old Horizons for an Ancient Drug: Pharmacokinetics, Pharmacodynamics, and Clinical Perspectives of Dimethyl Fumarate

Pharmaceutics, 2022
(1) Background: In their 60-year history, dimethyl fumarate and other salts of fumaric acid have been used for the treatment of psoriasis and other immune-mediated diseases for their immune-modulating properties.
Paolinelli Matteo, Diotallevi Federico, Martina Emanuela, Radi Giulia, Bianchelli Tommaso, Giacchetti Alfredo, Campanati Anna, Offidani Annamaria   +7 more
doaj   +1 more source