Results 21 to 30 of about 140,776 (178)

Impact of treatment with dimethyl fumarate on sleep quality in patients with relapsing-remitting multiple sclerosis: A multicentre Italian wearable tracker study

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2023
Background Sleep disorders are common in patients with multiple sclerosis and have a bidirectional interplay with fatigue and depression. Objective To evaluate the effect of treatment with oral dimethyl fumarate on the quality of sleep in relapsing ...
Giancarlo Comi, Letizia Leocani, Luigi Ferini-Strambi, Marta Radaelli, Gloria D Costa, Roberta Lanzillo, Giacomo Lus, Valentina Bianchi, Sebastiano Traccis, Fioravante Capone, Luigi ME Grimaldi, Giuseppe Salemi, Alessandra Cardillo, Valentina Zipoli,   +14 more
doaj   +1 more source

Dimethyl fumarate attenuates pain behaviors in osteoarthritis rats induction of Nrf2-mediated mitochondrial biogenesis

Molecular Pain, 2022
Osteoarthritis (OA), a chronic degenerative disease, leads to pain and loss of function. Existing treatments for OA pain have limited efficacy and show significant side effects.
Shao-Jie Gao, Dan-Yang Li, Dai-Qiang Liu, Jia Sun, Long-Qing Zhang, Jia-Yi Wu, Fan-He Song, Ya-Qun Zhou, Wei Mei   +8 more
doaj   +1 more source

Sleep-related breathing disorder (central sleep apnoea) improved coincidentally by medical therapy with fumarates (dimethyl fumarate)

, 2023
Central sleep apnoea (CSA) is a sleep disorder characterized by the repeated cessation or reduction of both airflow and ventilatory effort when sleeping.
Abdulmajeed M Albadi, Mana M Alshahrani, Riyad O Allehebi   +2 more
core   +1 more source

Dimethyl Fumarate Used as an Effective Treatment for Granuloma Annulare Disseminatum: An Immunohistochemical Case Study [PDF]

, 2023
This investigation demonstrates the use of dimethyl fumarate (DMF) for the treatment of disseminated granuloma annulare (GAD), a rare and chronic inflammatory skin disease.
Simon Bossart, Gabutti, Max, Bossart, Simon, Laurence Feldmeyer, Kristine Heidemeyer, Yawalkar, Nikhil, Seyed Jafari, S Morteza, Hunger, Robert E, Nikhil Yawalkar, Max Gabutti, S. Morteza Seyed Jafari, Heidemeyer, Kristine, Feldmeyer, Laurence, Robert E. Hunger   +13 more
core   +2 more sources

Overall and patient-level comparative effectiveness of dimethyl fumarate and fingolimod: A precision medicine application to the Observatoire Français de la Sclérose en Plaques registry

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2022
Background Comparing real-world effectiveness and tolerability of therapies for relapsing-remitting multiple sclerosis is increasingly important, though average treatment effects fail to capture possible treatment effect heterogeneity.
Gabrielle Simoneau, Xiaotong Jiang, Fabien Rollot, Lu Tian, Massimiliano Copetti, Matthieu Guéry, Marta Ruiz, Sandra Vukusic, Carl de Moor, Fabio Pellegrini,   +10 more
doaj   +1 more source

Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage

Neurobiology of Disease, 2015
Background and purpose: Edema formation, inflammation and increased blood–brain barrier permeability contribute to poor outcomes after intracerebral hemorrhage (ICH).
Loretta O. Iniaghe, Paul R. Krafft, Damon W. Klebe, Eric K.I. Omogbai, John H. Zhang, Jiping Tang   +5 more
doaj   +1 more source

Safety and persistence of dimethyl fumarate as a treatment for relapsing-remitting multiple-sclerosis [PDF]

Farmacia Hospitalaria, 2021
Objective: Dimethyl fumarate is a medication approved for the treatment of relapsing-remitting multiple sclerosis. The purpose of the study was to evaluate the safety and persistence of dimethyl fumarate in clinical practice and analyze the ...
Silvia Boullosa-Lale, Lara González-Freire, Luciano Martínez-Martínez, Carlos Crespo-Diz   +3 more
doaj   +1 more source

The Role of Glutathione-S Transferase in Psoriasis and Associated Comorbidities and the Effect of Dimethyl Fumarate in This Pathway

Frontiers in Medicine, 2022
Psoriasis vulgaris is a chronic inflammatory skin disease characterized by well-demarcated scaly plaques. Oxidative stress plays a crucial role in the psoriasis pathogenesis and is associated with the disease severity.
Elena Campione, Sara Mazzilli, Monia Di Prete, Monia Di Prete, Annunziata Dattola, Terenzio Cosio, Daniele Lettieri Barbato, Daniele Lettieri Barbato, Gaetana Costanza, Caterina Lanna, Valeria Manfreda, Ruslana Gaeta Schumak, Francesca Prignano, Filadelfo Coniglione, Fabrizio Ciprani, Katia Aquilano, Luca Bianchi   +16 more
doaj   +1 more source

Efficacy and safety of dimethyl fumarate in treatment-naïve Japanese patients with multiple sclerosis: Interim analysis of the randomized placebo-controlled study

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2019
Background The use of dimethyl fumarate has not been reported in treatment-naïve Japanese patients with relapsing–remitting multiple sclerosis. Objectives The purpose of this study was to evaluate the efficacy and safety of dimethyl fumarate in treatment-
Masahiro Mori, Takashi Ohashi, Yasuhiro Onizuka, Katsutoshi Hiramatsu, Masakazu Hase, Jang Yun, André Matta, Shinichi Torii   +7 more
doaj   +1 more source

DNA methylation changes in CD4 T cells isolated from multiple sclerosis patients on dimethyl fumarate

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018
Background Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood. Objective To investigate the effects of dimethyl fumarate on DNA methylation in the CD4 + T cells of multiple sclerosis patients.
Vicki E Maltby, Rodney A Lea, Karen A Ribbons, Katherine A Sanders, Daniel Kennedy, Myintzu Min, Rodney J Scott, Jeannette Lechner-Scott   +7 more
doaj   +1 more source