Pharmaceutics, 2022 (1) Background: In their 60-year history, dimethyl fumarate and other salts of fumaric acid have been used for the treatment of psoriasis and other immune-mediated diseases for their immune-modulating properties.
Matteo Paolinelli +2 more
exaly +4 more sources
Dimethyl Fumarate vs. Monomethyl Fumarate: Unresolved Pharmacologic Issues [PDF]
PharmaceuticsDimethyl fumarate (DMF) has established a significant position among therapies for multiple sclerosis and psoriasis and is now being investigated for repurposing to many other non-malignant diseases.
Jana Kopincova, Iveta Bernatova
doaj +3 more sources
Real-world discontinuation rate of teriflunomide and dimethyl fumarate in multiple sclerosis [PDF]
Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2021 Background For patients with MS, medication switches increase the risk of disease reactivation. Objective Compare discontinuation rates due to treatment failure or side effects between teriflunomide and dimethyl fumarate, and investigate clinical ...
Hilde Norborg +4 more
doaj +2 more sources
Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing-Remitting MS. [PDF]
Ann Clin Transl NeurolABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
Shawket F +14 more
europepmc +2 more sources
Cost‐Effectiveness of Dimethyl Fumarate Versus Teriflunomide in Patients With Relapsing‐Remitting Multiple Sclerosis (RRMS) in Iran [PDF]
Health Science ReportsBackground and Aims Multiple sclerosis (MS) is an autoimmune disorder that damages the myelin sheath on nerve fibers in the central nervous system, leading to axonal damage and neuron death.
Maryam Poursadeghfard +6 more
doaj +2 more sources
Hepato‐Renal Protective Potential of Dimethyl Fumarate in Alloxan‐Induced Diabetic Mice Model by Modulating of Sirt1, Nrf2 and Inflammatory Genes Expressions [PDF]
Endocrinology, Diabetes & MetabolismAim Despite advances in diabetes treatments, the effects of this disease have not yet been adequately reversed or prevented in patients. Therefore, development of more effective medication‐assisted treatments in this field is needed.
Parisa Saberi‐Hasanabadi +5 more
doaj +2 more sources
Evaluation of the effects of dimethyl fumarate on transforming growth factor beta levels in the liver of rats with bile duct ligation-induced cholestasis [PDF]
Toxicology ReportsBackground: Cholestasis is a reduction or cessation of bile flow in the biliary system, which can be life-threatening. Dimethyl Fumarate could induce anti-inflammatory and antioxidant effects in the body.
Hannaneh Vossoughi +3 more
doaj +2 more sources
Dimethyl fumarate transfer into human milk
Therapeutic Advances in Neurological Disorders, 2020 Dimethyl fumarate (DMF) is approved for the treatment of relapsing-remitting multiple sclerosis. It is unknown whether DMF or its primary metabolite monomethyl fumarate (MMF) are excreted into human milk.
Thomas W Hale +2 more
exaly +2 more sources
Transcriptome Analysis of Dimethyl Fumarate Inhibiting the Growth of Aspergillus carbonarius [PDF]
ToxinsAspergillus carbonarius is one of the main pathogens responsible for postharvest diseases in fruits and is also one of the main ochratoxin A-producing strains. It not only causes significant economic losses but also poses a risk to human health. We found
Siruo Wang +6 more
doaj +2 more sources
Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?
Pharmaceuticals, 2020 Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is approved and registered for the treatment of psoriasis and Relapsing ...
Stephanie Kourakis +2 more
exaly +3 more sources