JID Innovations, 2021 Dimethyl fumarate (DMF) is an effective oral treatment for psoriasis administered in Europe for nearly 60 years. However, its potential has been limited by contact dermatitis that prohibits topical application.
Krzysztof Bojanowski +4 more
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Neurobiology of Disease, 2015 Background and purpose: Edema formation, inflammation and increased blood–brain barrier permeability contribute to poor outcomes after intracerebral hemorrhage (ICH).
Loretta O. Iniaghe +5 more
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Dimethyl fumarate modulates antioxidant and lipid metabolism in oligodendrocytes
Redox Biology, 2015 Oxidative stress contributes to pathology associated with inflammatory brain disorders and therapies that upregulate antioxidant pathways may be neuroprotective in diseases such as multiple sclerosis.
He Huang +2 more
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Dimethyl fumarate as a safe and effective therapy for recalcitrant psoriasis in comorbid patients
Dermatology Reports, 2021 Psoriasis is a chronic condition for which multiple therapies are currently available. In particular, in cases of moderate-severe psoriasis, traditional systemic drugs or the new biological drugs can be administered.
Martina Burlando +3 more
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Production, characterization and determination of the real catalytic properties of the putative "succinate dehydrogenase" from Wolinella succinogenes [PDF]
, 2009 Both the genomes of the epsilonproteobacteria Wolinella succinogenes and Campylobacter jejuni contain operons (sdhABE) that encode for so far uncharacterized enzyme complexes annotated as ‘non-classical’ succinate:quinone reductases (SQRs).
Ackrell +71 more
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Effectiveness of delayed-release dimethyl fumarate on patient-reported outcomes and clinical measures in patients with relapsing-remitting multiple sclerosis in a real-world clinical setting: PROTEC. [PDF]
, 2019 Ensaio clínico PROTEC, Protocolo nº 109MS408Abstract BACKGROUND: Patient-reported outcomes (PRO) and clinical outcomes give a broad assessment of relapsing-remitting multiple sclerosis (RRMS) disease.
Berger, T +5 more
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USE OF DIMETHYL FUMARATE IN THE TREATMENT OF MULTIPLE SCLEROSIS: CLINICAL AND ECONOMIC ANALYSIS
Неврология, нейропсихиатрия, психосоматика, 2016 The paper presents a review of an update on the comparative pharmacoeconomic analysis of using dimethyl fumarate in the treatment of multiple sclerosis (MS) in European countries. A pharmacoeconomic evaluation was made to study the use of first-line oral
V. R. Mkrtchyan +3 more
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Acta Crystallographica Section E Structure Reports Online, 2004 Dimethyl fumarate, C6H8O4, crystallizes in the fully stretched planar conformation. The molecule is located on a crystallographic inversion centre and has local symmetry 2/m. The fumarate molecules aggregate in layers coinciding with the (1\overline 11) lattice planes.
Kooijman, H. +4 more
openaire +4 more sources
Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress [PDF]
, 2018 Reactive oxygen species (ROS) are increasingly recognised as important signalling molecules through oxidation of protein cysteine residues. Comprehensive identification of redox-regulated proteins and pathways is crucial to understand ROS-mediated events.
Gottlieb, Eyal +4 more
core +2 more sources
Calming the (Cytokine) Storm: Dimethyl Fumarate as a Therapeutic Candidate for COVID-19
Pharmaceuticals, 2020 COVID-19 has rapidly spread worldwide and incidences of hospitalisation from respiratory distress are significant. While a vaccine is in the pipeline, there is urgency for therapeutic options to address the immune dysregulation, hyperinflammation and ...
Cara A. Timpani, Emma Rybalka
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