Results 51 to 60 of about 30,023 (217)

Relapsing-remitting multiple sclerosis: advances in disease-modifying therapies [PDF]

, 2015
Multiple sclerosis is a demyelinating disease affecting the central nervous system. It is the most prevalent disabling neurological condition among young adults, with onset typically between 20 and 40 years of age. Infiltrating immune cells and microglia
Kay, Kathleen Alexandra
core   +1 more source

A functional description of CymA, an electron-transfer hub supporting anaerobic respiratory flexibility in Shewanella [PDF]

, 2012
CymA (tetrahaem cytochrome c) is a member of the NapC/NirT family of quinol dehydrogenases. Essential for the anaerobic respiratory flexibility of shewanellae, CymA transfers electrons from menaquinol to various dedicated systems for the reduction of ...
Butt, Julea N., Bye, Jordan, Cheesman, Myles R., Fredrickson, Jim, Jeuken, Lars J. C., Lowe, Thomas G., Marritt, Sophie J., McMillan, Duncan G. G., Richardson, David J., Shi, Liang, Zachara, John   +10 more
core   +1 more source

Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund, Johan Reutfors, Thomas Frisell, Fredrik Piehl   +3 more
wiley   +1 more source

Rapid determination of dimethyl fumarate in beverages by dispersed liquid-liquid microextraction with ultrasound-assisted and high performance liquid chromatography

Shipin yu jixie
ObjectiveTo establish a rapid detecting method for the determination of dimethyl fumarate in beverages by ultrasound-assisted dispersive liquid-liquid micro-extraction coupled with high performance liquid chromatography.MethodsThe beverage samples were ...
JIANG Fangjun, LIANG Feng, FENG Yalong, LI Qiuyi, DING Fanglin, ZHANG Zhaohui   +5 more
doaj   +1 more source

Block Copolymers: Emerging Building Blocks for Additive Manufacturing

Advanced Functional Materials, EarlyView.
This review addresses how block copolymer (BCP) physics and rheology have led to the widespread use of BCPs in advanced additive manufacturing techniques, with particular emphasis on the untapped potential of these nanostructured materials toward achieving multi‐scale architected materials with unique, programmable material properties.
Alice S. Fergerson, Hemish B. Thakkar, Jiaen Wu, Emily C. Davidson   +3 more
wiley   +1 more source

Unexpected one-pot formation of the 1H-6a,8a-epiminotricyclopenta[a,c,e][8]annulene system from cyclopentanone, ammonia and dimethyl fumarate. Synthesis of highly strained polycyclic nitroxide and EPR study

Beilstein Journal of Organic Chemistry, 2019
The unexpected formation of a highly strained polycyclic amine was observed in a one-pot synthesis from cyclopentanone, dimethyl fumarate and ammonium acetate.
Sergey A. Dobrynin, Igor A. Kirilyuk, Yuri V. Gatilov, Andrey A. Kuzhelev, Olesya A. Krumkacheva, Matvey V. Fedin, Michael K. Bowman, Elena G. Bagryanskaya   +7 more
doaj   +1 more source

Cascade oxime formation, cyclization to a nitrone, and intermolecular dipolar cycloaddition. [PDF]

, 2016
Simple haloaldehydes, including enolisable aldehydes, were found to be suitable for the formation of cyclic products by cascade (domino) condensation, cyclisation, dipolar cycloaddition chemistry.
Aasen, Ali, Ali, Burdisso, Burdisso, Burrell, Burrell, Burrell, Burrell, Coldham, Coldham, Coldham, Coldham, Coldham, Coldham, Davison, Denmark, Deno, Flick, Grashey, Grigg, Ha, Harry Adams, Heather E. Holberry, Huisgen, Hélène D. S. Guerrand, Iain Coldham, Ito, Jonathan R. Shewring, Laemmerhold, LeBel, Ma, Mulzer, Page, Pandey, Peng, Rachel C. Furnival, Revuelta, Rungroj Saruengkhanphasit, Rüeger, Sarkar, Sengoku, Shono, Siriwardena, Stockman, Suneel Kumar, Tufariello, Wilson, Yamato   +48 more
core   +1 more source

Dimethyl Fumarate Treatment Reduces the Amount but Not the Avidity of the Epstein–Barr Virus Capsid-Antigen-Specific Antibody Response in Multiple Sclerosis: A Pilot Study [PDF]

, 2023
Massimiliano Castellazzi, Caterina Ferri, Alice Piola, Samantha Permunian, Gaia Buscemi, Michele Laudisi, Eleonora Baldi, Maura Pugliatti   +7 more
openalex   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Dimethyl fumarate ameliorates chemotherapy agent-induced neurotoxicity in vitro

Journal of Pharmacological Sciences, 2018
Chemotherapy agents such as oxaliplatin, cisplatin, paclitaxel, and bortezomib frequently cause severe peripheral neuropathy and there is currently no effective strategy to prevent this.
Takehiro Kawashiri, Anna Miyagi, Shiori Shimizu, Nao Shigematsu, Daisuke Kobayashi, Takao Shimazoe   +5 more
doaj   +1 more source