Results 71 to 80 of about 687 (125)

A real-world comparison of relapse rates, healthcare costs and resource use among patients with multiple sclerosis newly initiating subcutaneous interferon beta-1a versus oral disease-modifying drugs

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018
Background Administrative-claims data enable comparative effectiveness assessment using large numbers of patients treated in real-world settings. Objective To evaluate real-world relapses, healthcare costs and resource use in patients with MS newly ...
James D Bowen, Chris M Kozma, Megan M Grosso, Amy L Phillips   +3 more
doaj   +1 more source

Health Literacy and Unmet Needs in Patients With Multiple Sclerosis: A Cross‐Sectional Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aims To identify a correlation between unmet needs and HL levels in people with Multiple Sclerosis (pwMS) and to evaluate how sociodemographic characteristics influence HL levels and unmet needs. Design A cross‐sectional study. Methods The study was conducted using a questionnaire including the HLS19‐Q12 to assess HL and the Long‐term Unmet ...
Francesco Pastore, Barbara Forastefano, Valentina Simonetti, Tommaso Guerra, Giancarlo Cicolini, Pietro Iaffaldano, Dania Comparcini   +6 more
wiley   +1 more source

Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro.

PLoS ONE, 2015
Delayed-release dimethyl fumarate (also known as gastro-resistant dimethyl fumarate), an oral therapeutic containing dimethyl fumarate (DMF) as the active ingredient, is currently approved for the treatment of relapsing multiple sclerosis.
Melanie S Brennan, Maria F Matos, Bing Li, Xiaoping Hronowski, Benbo Gao, Peter Juhasz, Kenneth J Rhodes, Robert H Scannevin   +7 more
doaj   +1 more source

Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor, Kavita Verma, Nishu, Barkat Hussain, Vartika Mathur   +4 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Drugst.One DREAM—Drug repurposing through expert annotation and modification

British Journal of Pharmacology, Volume 183, Issue 13, Page 3503-3516, July 2026.
Background and Purpose Complex diseases often lack an actionable understanding of their underlying causal biological mechanisms, which leads to treating symptoms rather than causes. Network and systems medicine define disease mechanisms through disease‐associated genes, their encoded proteins and their protein–protein interactions (PPIs), thus forming ...
Lisa M. Spindler, Johannes Kersting, Quirin Manz, Michael Hartung, Andreas Maier, Zeinab M. Mamdouh, Ana I. Casas, Jan Baumbach, Markus List   +8 more
wiley   +1 more source

Pharmacological Activation of NRF2 by Omaveloxolone Upregulates NRF2‐Target Proteins in SMA Type I Human Fibroblasts

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
SMA type I patient‐derived fibroblasts exhibit reduced basal NRF2 pathway output, reflected by decreased NQO1, xCT, and PGC1α. Pharmacological NRF2 activation with omaveloxolone (OMAV) increases cell viability and induces NRF2 target proteins in both control and SMA fibroblasts.
Sofia Vrettou, Sebastian Zetzsche, Brunhilde Wirth   +2 more
wiley   +1 more source

AIEgen Targets the STAT3‒SUCLG2 Axis to Regulate Metabolism for Colorectal Cancer Theranostics

Aggregate, Volume 7, Issue 6, June 2026.
In CRC, TPA‐FB directly binds to STAT3 and blocks its phosphorylation. It reduces SUCLG2 expression, disrupts mitochondrial function and modulates protein succinylation. Our work highlights that targeting oncogenic STAT3, TPA‐FB rewires metabolism and inhibits CRC progression.
Shaomin Zou, Dan Zhong, Song Xiang, Jieping Zhang, Ruijia Zhang, Ziqing Yang, Manqi Meng, Kuiheng Chen, Ling Fang, Bart Ghesquiere, Hai‐Tao Feng, Ben Zhong Tang, Lekun Fang   +12 more
wiley   +1 more source

A Comprehensive Disproportionality Analysis of Drug‐Related Head Injury Reports Using the FAERS Database

Brain and Behavior, Volume 16, Issue 6, June 2026.
ABSTRACT Objective This study aimed to identify and characterize drugs associated with reports of head injury through a comprehensive analysis of the FDA Adverse Event Reporting System (FAERS) database. Methods A retrospective disproportionality analysis was conducted on FAERS reports from 2004 to 2023.
Jiaqi Guo, Luming Wei, Junfeng Liu, Jimei Zhang, He Wang, Wanjun Lu   +5 more
wiley   +1 more source

Association of Neurodevelopmental Disorders and Congenital Anomalies With Prenatal Multiple Sclerosis Treatment—Real‐World Historical Cohort Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1565-1573, June 2026.
There is a paucity of data regarding the effects of prenatal disease‐modifying therapies (DMTs) for multiple sclerosis (MS), on congenital anomalies in the offspring. Moreover, data on the association with neurodevelopmental disorders are lacking. This is an historical cohort study, within the Israeli Clalit Health Services database (2005–2024) that ...
Bar Rosh, Ofek Levi, Nili Stein, Amir Yahav, Naomi Gronich   +4 more
wiley   +1 more source