Results 71 to 80 of about 140,776 (178)

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Dimethyl fumarate potentiates oncolytic virotherapy through NF-κB inhibition

, 2018
Dimethyl fumarate combined with oncolytic virus increases its potency in cancer treatment.
Ramya Krishnan, Brian A. Keller, Paula Ou, Carolina Ilkow, John C. Bell, Anabel Bergeron, Larissa Pikor, Andrew Chen, Christopher Rousso, Mohammed Selman, Jean-Simon Diallo   +10 more
core   +1 more source

Rapid determination of dimethyl fumarate in beverages by dispersed liquid-liquid microextraction with ultrasound-assisted and high performance liquid chromatography

Shipin yu jixie
ObjectiveTo establish a rapid detecting method for the determination of dimethyl fumarate in beverages by ultrasound-assisted dispersive liquid-liquid micro-extraction coupled with high performance liquid chromatography.MethodsThe beverage samples were ...
JIANG Fangjun, LIANG Feng, FENG Yalong, LI Qiuyi, DING Fanglin, ZHANG Zhaohui   +5 more
doaj   +1 more source

Dimethyl fumarate in the management of multiple sclerosis: appropriate patient selection and special considerations

, 2016
Luca Prosperini, Simona Pontecorvo Department of Neurology and Psychiatry, Sapienza University, Rome, Italy Abstract: Delayed-release dimethyl fumarate (DMF), also known as gastroresistant DMF, is the most recently approved oral disease-modifying ...
Prosperini L, Pontecorvo S
core  

Unexpected one-pot formation of the 1H-6a,8a-epiminotricyclopenta[a,c,e][8]annulene system from cyclopentanone, ammonia and dimethyl fumarate. Synthesis of highly strained polycyclic nitroxide and EPR study

Beilstein Journal of Organic Chemistry, 2019
The unexpected formation of a highly strained polycyclic amine was observed in a one-pot synthesis from cyclopentanone, dimethyl fumarate and ammonium acetate.
Sergey A. Dobrynin, Igor A. Kirilyuk, Yuri V. Gatilov, Andrey A. Kuzhelev, Olesya A. Krumkacheva, Matvey V. Fedin, Michael K. Bowman, Elena G. Bagryanskaya   +7 more
doaj   +1 more source

Dimethyl fumarate ameliorates chemotherapy agent-induced neurotoxicity in vitro

Journal of Pharmacological Sciences, 2018
Chemotherapy agents such as oxaliplatin, cisplatin, paclitaxel, and bortezomib frequently cause severe peripheral neuropathy and there is currently no effective strategy to prevent this.
Takehiro Kawashiri, Anna Miyagi, Shiori Shimizu, Nao Shigematsu, Daisuke Kobayashi, Takao Shimazoe   +5 more
doaj   +1 more source

Dimethyl Fumarate Attenuates Microglia Activation and Long-Term Memory Deficits Following Systemic Immune Challenge

, 2017
Peripheral systemic inflammation is associated with increased cognitive decline and higher risk of developing Alzheimer’s disease. Microglia activated during systemic inflammation can cause exaggerated neuroinflammatory responses and trigger chronic ...
Paraiso, Hallel C
core   +1 more source

Incidence of type 2 diabetes, cardiovascular disease and chronic kidney disease in patients with multiple sclerosis initiating disease-modifying therapies: Retrospective cohort study using a frequentist model averaging statistical framework.

PLoS ONE
Researchers are increasingly using insights derived from large-scale, electronic healthcare data to inform drug development and provide human validation of novel treatment pathways and aid in drug repurposing/repositioning.
Alan J M Brnabic, Sarah E Curtis, Joseph A Johnston, Albert Lo, Anthony J Zagar, Ilya Lipkovich, Zbigniew Kadziola, Megan H Murray, Timothy Ryan   +8 more
doaj   +1 more source

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source