Results 91 to 100 of about 140,776 (178)
Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy
Allergy, EarlyView.Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan +16 more
wiley +1 more source
Comparative analysis of dimethyl fumarate and fingolimod in relapsing-remitting multiple sclerosis.
, 2020 BACKGROUND Dimethyl fumarate and fingolimod are oral disease modifying treatments (DMTs) that reduce relapse activity and slow disability worsening in relapsing-remitting multiple sclerosis (RRMS).
Benkert P +7 more
core +1 more source
PLoS ONE, 2015 Delayed-release dimethyl fumarate (also known as gastro-resistant dimethyl fumarate), an oral therapeutic containing dimethyl fumarate (DMF) as the active ingredient, is currently approved for the treatment of relapsing multiple sclerosis.
Melanie S Brennan +7 more
doaj +1 more source
Acta Zoologica, EarlyView.ABSTRACT Halyomorpha halys (Stål, 1855) is an invasive pentatomid species causing considerable economic losses in agricultural systems. Despite the ecological importance of the metathoracic scent gland (MTG) in chemical defence and communication, detailed information on its morphology and secretion composition remains limited. In the present study, the
Sila Aydin, Suat Kiyak
wiley +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Solid-liquid equilibria for the dimethyl ether plus carbon dioxide binary system [PDF]
, 2010 A recently built experimental setup was employed for the estimation of the solid-liquid equilibria of alternative refrigerants systems. The behavior of dimethyl ether (DME) + carbon dioxide was measured down to temperatures of 131.6 K.
Di Nicola, G. +11 more
core +1 more source
Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.Protic molecules containing strong O─H or N─H bonds typically resist hydrogen‐atom abstraction because of the high reactivity of the resulting heteroatom‐centered radicals. However, association of the protic molecules with redox‐active Lewis acids can provide powerful hydrogen‐atom donors or proton‐coupled‐electron‐transfer reagents.
Petra Vojáčková, Armido Studer
wiley +2 more sources
Contact Dermatitis, EarlyView.ABSTRACT Background Over‐ear headphones are a growing source of allergic contact dermatitis (ACD). Identifying well‐known and new culprit sensitizers in such products is challenging because of a lack of labelling and limited cooperation from manufacturers.
Goël Fenech +5 more
wiley +1 more source
TNF-α and IL-6 levels in Multiple Sclerosis on Dimethyl Fumarate: A Retrospective Study
This 6-year retrospective study evaluated correlations between TNF-α, IL-6, EDSS, vitamin D levels, age, duration of disease, or number of MRI lesions in in attack-free MS patients on dimethyl fumarate.
Xinping Cui, Song Zhai, William S. Baek
core +1 more source
Catastrophic relapses following initiation of dimethyl fumarate in two patients with neuromyelitis optica spectrum disorder [PDF]
, 2017 We report two cases of neuromyelitis optica spectrum disorder (NMOSD) who were misdiagnosed as multiple sclerosis (MS) and developed catastrophic relapses following initiation of dimethyl fumarate.
Bassem I Yamout +7 more
core +1 more source