Results 261 to 270 of about 349,747 (354)

Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease

Advanced Science, EarlyView.
This study presents the NEV β‐secretase activity assay, a groundbreaking method for noninvasive evaluation of β‐secretase activity in Alzheimer's disease (AD) patients, enabling the generation of individualized β‐secretase activity profiles.
Hyoyong Kim, Junseok Lee, Audrey Qian, You‐Ren Ji, Ryan Zhang, Qixin Hu, Christopher Kazu Williams, Han‐Yu Chuang, Matthew D. Smalley, Yaya Xu, Liang Gao, Mary C. Mayo, Ting Zhang, Edwin M. Posadas, Zaldy S. Tan, Harry V. Vinters, Keith Vossel, Shino Magaki, Yazhen Zhu, Hsian‐Rong Tseng   +19 more
wiley   +1 more source

Bis[(dimethyl-λ\u3csup\u3e4\u3c/sup\u3e-sulfanylidene)oxonium] hexabromidotellurate(IV) dimethyl sulfoxide disolvate [PDF]

, 2008
Kokke, Gregory, Lindeman, Sergey V., Rudd, Martin D.   +2 more
core   +1 more source

RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy

Advanced Science, EarlyView.
RAB3B is unveiled as a prominent oncogenic regulator in chordoma, which can block the DUSP12‐mediated dephosphorylation of p‐S6 (S235/236). The combination of RAB3B and p‐S6 indicates a good prognostic value and predicts mTORC1 inhibitors response for chordoma patients.
Jianxuan Gao, Jiali Jin, Runzhi Huang, Siqiao Wang, Sihui Song, Yu Zhang, Yongai Li, Jun Lin, Zhengyan Chang, Zongqiang Huang, Wei Sun, Huabin Yin, Dianwen Song, Jianru Xiao, Ping Wang, Tong Meng   +15 more
wiley   +1 more source

Confined Migration Drives Stem Cell Differentiation

Advanced Science, EarlyView.
Human mesenchymal stem cell (hMSC) homing to sites of regeneration requires navigation through mechanically confining extracellular matrix environments, inducing rapid and dramatic morphological adaptation. By exposing hMSCs to specific levels of physiological confinement, it is demonstrated that confinement can induce osteogenesis, and that this fate ...
Xu Gao, Yixuan Li, Jia Wen Nicole Lee, Jianxuan Zhou, Vaishnavi Rangaraj, Jennifer Marlena, Andrew W. Holle   +6 more
wiley   +1 more source

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

Advanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma, Fei Ma, Ning Ding, Lin Xie, Anning Yang, Jiangyong Shen, Yun jiao, Kai Wu, YueE Chai, Zhigang Bai, Jiantuan Xiong, Nan Li, Huiping Zhang, Yideng Jiang   +13 more
wiley   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

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The Applications of Dimethyl Sulfoxide as Reagent in Organic Synthesis

Advanced Synthesis and Catalysis, 2016
Dimethyl sulfoxide (DMSO) is one of the most commonly applied organic solvents in chemical transformations and is utilized widely in industrial processes as well.
Kishore Natte, Xiao-feng Wu
exaly   +2 more sources

The Solvent Dimethyl Sulfoxide [PDF]

Angewandte Chemie International Edition in English, 1967
AbstractThe dipolar aprotic solvent dimethyl sulfoxide is liquid over a wide range of temperatures, is a strong electron donor, and has a high polarity. It is therefore an excellent and selective solvent for many organic and even polymeric compounds, and can enter into H‐bonding and dipole‐dipole association. The structure of dimethyl sulfoxide, with a
D. Martin, H.-J. Niclas, A. Weise
openaire   +2 more sources

Potential Explosion Hazards Associated with the Autocatalytic Thermal Decomposition of Dimethyl Sulfoxide and Its Mixtures

, 2020
Dimethyl sulfoxide (DMSO) is widely used as a solvent for chemical reactions, as a cosolvent for crop protection formulations, and in medicines for topical administration of drugs.
Qiang Yang, Min Sheng, Xiaoyong Li, Craig A. Tucker, Suhelen Vásquez Céspedes, Nicola J. Webb, G. Whiteker, Jing Yu   +7 more
semanticscholar   +1 more source

Cryoprotection by dimethyl sulfoxide and dimethyl sulfone

Cryobiology, 1987
Preservation of cells and tissues at low temperatures requires the presence of effective cryoprotectants with low toxicity to which cells are relatively permeable. Two similar compounds, dimethyl sulfoxide (DMSO) and dimethyl sulfone (DMSO2), exhibit both features for cryoprotectants, yet DMSO is a very effective cryoprotectant while DMSO2 is ...
Michele L. Walterson, Locksley E. McGann
openaire   +3 more sources