Results 51 to 60 of about 529,916 (333)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Characterizing the Interactions of Dimethyl Sulfoxide with Water: A Rotational Spectroscopy Study

, 2022
The interaction of dimethyl sulfoxide with water has been investigated by Fourier-transform microwave spectroscopy of the 1:1 complex and its isotopologues, complemented with quantum chemical calculations.
Luca Evangelisti (1291146), Giovanna Salvitti (4251283), Dingding Lv (13850048), Assimo Maris (1464358), Sonia Melandri (1395418), Wentao Song (109384)   +5 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

[1,2-Bis(diphenylphosphanyl)ethane-κ2P,P′]dichloridopalladium(II) dimethyl sulfoxide monosolvate

Acta Crystallographica Section E, 2012
In the title compound, [PdCl2(C26H24P2)]·C2H6OS, the PdII atom adopts a distorted cis-PdCl2P2 square-planar coordination geometry. The five-membered chelate ring adopts an envelope conformation with a methylene C atom in the flap position. The S
Ismail Warad, Abdullah S. Aldwayyan, Fahad M. Al-Jekhedab, M. Iqbal Choudhary, Sammer Yousuf   +4 more
doaj   +1 more source

Dimethyl sulfoxide [MAK Value Documentation, 2017]

, 2017
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated the possibility to add the indication “Prerequisite for Pregnancy Risk Group C” to the classification of Pregnancy Risk Group B for ...
Hartwig, A, et al, Arand, Michael; https://orcid.org/, MAK Commission   +3 more
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

trans-Bis(3-hydroxypyridine-κN)diiodidoplatinum(II) dimethyl sulfoxide disolvate

Acta Crystallographica Section E, 2011
In the title compound, [PtI2(C5H5NO)2]·2(CH3)2SO, the PtII ion lies on an inversion center and is coordinated in a slightly distorted square-planar environment by two trans iodide ligands and two pyridine N atoms.
Fazlul Huq, Muhammed Danish, Wojciech Starosta, Janusz Leciejewicz   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Dichlorido{N-[2-(diphenylphosphanyl)benzylidene]isopropylamine-κ2N,P}palladium(II) dimethyl sulfoxide monosolvate

Acta Crystallographica Section E, 2011
In the title PdII complex, [PdCl2(C22H22NP)]·(CH3)2SO, the PdII atom is coordinated in an NPCl2 coordination sphere by the N(imino) and P(phosphane) atoms of the ligand and by two Cl− ions in a slightly distorted square-planar geometry
Haleden Chiririwa, Reinout Meijboom, Bernard Omondi   +2 more
doaj   +1 more source

Dimethyl sulfoxide complexes of silver(I) in solution

, 1971
The stability constants of dimethyl sulforxide complexes of silver (I) in methanol, 2-butanol, acetone, sulfolane, 70% dioxane, and nitroethane were determined by potentiometric titrations. No dimethyl sulfoxide complexes of silver(I) are formed in water.
Hamm, David A., Luehrs, Dean C., Nicholas, Robert W.   +2 more
core   +1 more source