Results 91 to 100 of about 791,804 (284)

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Ovarian Reserve Test L The Use in Daily Clinical Practice

, 2013
To Evaluate the significance of conducting ovarian reserve testing decide when to order this testing in the clinical setting. and also to give individualized counseling to patients regarding the prognosis of infertility treatment based on their ovarian ...
Abdullah, Nusratuddin
core  

Effect of Yushen zhuyun decoction on rats with diminished ovarian reserve induced by tripterygium glycosides [PDF]

, 2017
Purpose: To investigate the effect of Yushen zhuyun decoction (YSZYF) on rats with diminished ovarian reserve (DOR).Methods: High-performance liquid chromatography (HPLC) was used to determine the major phytochemical constituents of YSZYF. Rats with DOR (
Zhuang, Mengfei, Hao, Lishuang, Tan, Li, Zhang, Ying, Zhang, Tingting, Jin, Yuli   +5 more
core   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Modified letrozole vs GnRH antagonist protocols in ovarian aging women for IVF: an open-label, multicenter, randomized controlled trial

Nature Communications
For women with diminished ovarian reserve or of advanced age, controlled ovarian stimulation presents a significant challenge during in vitro fertilization cycles.
Yang Zhao, Shuyun Zhao, Jiawen Xu, Jingbo Chen, Yun Lin, Yuhong Peng, Xuemei Li, Ping Pan, Jing Shu, Xiaojia Li, Jie Wang, Chu Chu, Rui Hu, Yiqi Yu, Yunting Zhang, Saif ur Rehman, Guanghui Dong, Dongzi Yang, Ricardo Azziz, Ben W. Mol, Yankai Xia, Xiaomiao Zhao   +21 more
doaj   +1 more source

Empty Follicle Syndrome: The Possible Cause of Occurrence

Oman Medical Journal, 2015
Objectives: Empty follicle syndrome (EFS), although rare, is a disappointing condition in which no oocytes are retrieved from mature follicle after ovulation induction in in vitro fertilization (IVF) cycles.
Tahereh Madani, Nadia Jahangiri
doaj   +1 more source

Role of oral dehydroepiandrosterone in diminished ovarian function [PDF]

, 2017
Background: Ovarian reserve decreases with age and this study determine the effect of oral DHEA supplementation on S.AMH concentration and conception rate in women with diminished ovarian function.Methods: The study was conducted on 72 infertile women of
Dayal, Meena, Chaurasia, Amrita, Patel, Shweta, Singh, Urvashi, Gupta, Veena   +4 more
core   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Human ovarian reserve from conception to the menopause [PDF]

, 2009
Current understanding is that the human ovary contains a fixed number of several million non-growing follicles (NGF), established by five months of gestational age, that declines with increasing age to the menopause when approximately 1,000 NGF remain at
Thomas W Kelsey, Kelsey, Tom, W Hamish B Wallace, Wallace W. Hamish B., William H. B. Wallace, Thomas W. Kelsey, Wallace, W. Hamish B., Kelsey Thomas W., Kelsey, Tom; id_orcid   +8 more
core   +1 more source