Results 81 to 90 of about 791,804 (284)

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

Only Female Age, and Not Blood Type, Is Associated with Ovarian Reserve [PDF]

International Journal of Fertility and Sterility, 2014
Background The association between blood types and ovarian reserve is investigated in this study. Materials and Methods As an index of ovarian reserve, women with a follicle stimulat- ing hormone (FSH) level of ≥10 mIU/ml in the early follicular ...
Özlem Şengül, Berna Dilbaz, Neslihan Yerebasmaz, Suat Dede, Şadıman Altınbaş, Salim Erkaya   +5 more
doaj  

Ovarian volume throughout life : a validated normative model [PDF]

, 2013
The measurement of ovarian volume has been shown to be a useful indirect indicator of the ovarian reserve in women of reproductive age, in the diagnosis and management of a number of disorders of puberty and adult reproductive function, and is under ...
Dodwell, Sarah, Wilkinson, A Graham, Sarah K. Dodwell, Andersen, Claus, Wallace, W Hamish B, Claus Y Andersen, Thomas W Kelsey, Richard A Anderson, Wallace, Hamish, Andersen, Claus Y, Wilkinson A. Graham, Dodwell, Sarah K, Wallace W. Hamish B, Andersen Claus Y., A Graham Wilkinson, Kelsey, Thomas W, Kelsey, Tom, Richard A. Anderson, Dodwell Sarah K., Greve, Tine, W. Hamish B Wallace, Thomas W. Kelsey, Claus Y. Andersen, Kelsey Thomas W., Anderson, Richard, Tine Greve, W Hamish B Wallace, Greve Tine, Anderson Richard A., Anderson, Richard A, Sarah K Dodwell, Wilkinson, Graham, A. Graham Wilkinson, Kelsey, Tom; id_orcid   +33 more
core   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Diminished Ovarian Reserve, Causes, Assessment and Management

International Journal of Infertility & Fetal Medicine, 2013
ABSTRACTDiminished ovarian reserve predicts diminished ovarian response to stimulation but does not predict cycle fecundity. It has been recently defined by ESHRE, the Bologna's criteria, according to which at least two of the following three features should be present: (1) Age >40 years/any other risk factor for DOR, (2) abnormal ovarian reserve ...
Mala Arora, Mandeep Kaur
openaire   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Ovarian reserve diminished by oral cyclophosphamide therapy for granulomatosis with polyangiitis (Wegener's) [PDF]

, 2011
Objective Standard treatment for severe granulomatosis with polyangiitis (Wegener's) (GPA) is daily oral cyclophosphamide (CYC), a cytotoxic agent associated with ovarian failure.
Peter A. Merkel, Hsieh, Tsung-cheng, Ytterberg, Steven R., Shein-Chung Chow, Hoffman, Gary S., Megan E. B. Clowse, Robert F. Spiera, Allen, Nancy B., Nancy B. Allen, Tsung-Cheng Hsieh, W. Joseph McCune, McCune, William Joseph, E. William St.Clair, Copland, Susannah C., Davis, John C., John H. Stone, Clowse, Megan E. B., John C. Davis, Spiera, Robert F., Steven R. Ytterberg, Susannah C. Copland, Specks, Ulrich, Merkel, Peter A., Gary S. Hoffman, Ulrich Specks, null null, St.Clair, E. William, Stone, John H., Chow, Shein‐chung   +28 more
core   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

Integrative Management of Acupuncture for Diminished Ovarian Reserve with Insomnia: Study Protocol for a Prospective Randomized Controlled Trial [PDF]

Yuanyuan Lai,1,* Dan Chen,1,* Chunhui Tian,1 Yufei Huang,1 Di Gan,1,2 Liying Liu,1 Jie Yang1,3 1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Department of ...
Lai Y, Yang J, Huang Y, Liu L, Tian C, Gan D, Chen D   +6 more
core  

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source