Results 11 to 20 of about 1,009 (89)

EMF2 deficiency disrupts epigenetic and chromatin organization landscapes, blocking root regeneration competence in Arabidopsis

New Phytologist, EarlyView.
EMF2 mutation alters transcriptomic profiles in Arabidopsis calli while retaining responsiveness during root induction. Summary Plant de novo organogenesis depends on callus formation, yet the epigenetic mechanisms governing organ regeneration remain poorly understood.
Zhidan Wang, May Avraham, Tali Mandel, Leor Eshed Williams, Chang Liu   +4 more
wiley   +1 more source

Salt Stress Induces Imbalanced ADI Pathway Gene Expressions in Pediococcus acidilactici Drives Citrulline Accumulation as an Ethyl Carbamate Precursor in Soy Sauce

Food Bioengineering, Volume 5, Issue 2, Page 171-181, June 2026.
ABSTRACT Citrulline is the main precursor of a carcinogen compound ethyl carbamate (EC) in soy sauce. Accumulation of citrulline is mainly related to metabolism of arginine by Pediococcus acidilactici via the arginine deiminase (ADI) pathway during soy sauce fermentation.
Xiaodie Chen, Jiran Zhang, Haoran Chen, Fang Fang   +3 more
wiley   +1 more source

Direct Access to Acylboranes via Formal Condensation of Carboxylic Acids with Ligated Boranes

Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.
A nickel‐catalyzed, radical‐based C(acyl)–B cross‐coupling strategy has been developed for the efficient synthesis of bench‐stable, phosphonite‐ligated acylborane compounds from readily available carboxylic acids. This methodology not only provides access to acylboranes with diverse reactivity profiles but also establishes a versatile platform for the ...
Chen‐Yan Cai, Chao Hu, Katherine E. Colbaugh, Rohan R. Merchant, Shuming Chen, Tian Qin   +5 more
wiley   +2 more sources

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

MedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao   +12 more
wiley   +1 more source

A Structural Context for the Mechanisms of Uncoupling Protein 1 in Brown Fat Thermogenesis

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Uncoupling Protein 1 (UCP1) is a defining feature of brown fat and facilitates the specialized ability of the tissue to generate heat in the process of non‐shivering thermogenesis. The protein is activated by fatty acids, which overcome its inhibition by purine nucleotides, to catalyze proton leak across the mitochondrial inner membrane ...
Riccardo Cavalieri, Margeoux A. S. Dela Rosa, Camila A. Cotrim, Danielle Copeman, Mehmethan Aris, Callum Eke, Hannah Staggs‐Sandy, Paul G. Crichton   +7 more
wiley   +1 more source

Docetaxel‐Induced Immune Activation Shows Antitumor Synergy With the Tumor‐Targeted CD40 Agonist KK2269

Cancer Science, Volume 117, Issue 6, Page 1701-1712, June 2026.
CD40 agonists have demonstrated proof‐of‐concept for converting an immunologically cold tumor into a hot tumor in preclinical studies; however, clinically, they have shown limited antitumor efficacy as monotherapy. We tested a tumor‐targeted CD40 agonist, KK2269 (a bispecific antibody that binds to CD40 and EpCAM), in combination with various ...
Yuta Tezuka, Kyoko Kawasaki, Yoshiki Sumitomo, Masato Saito, Akari Yao, Munetoshi Ando   +5 more
wiley   +1 more source

Selective Retention of Phenolics From Pomegranate and Sour Cherry Juices Using Protein‐Functionalized Electrospun Membranes

Journal of Food Process Engineering, Volume 49, Issue 6, June 2026.
Protein‐functionalized electrospun nanofiber membranes selectively retain high‐value phenolic compounds from pomegranate and sour cherry juices. This novel filtration approach preserves these phenolic antioxidants during processing, demonstrating superior selective separation and retention performance.
Farzaneh Azizzadeh, Filiz Altay
wiley   +1 more source

Growth differentiation factor 15 mitigates lipotoxic steatosis by preserving mitochondrial morphodynamics and augmenting fatty acid oxidation in hepatocytes and liver organoids

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3788-3806, May 2026.
Abstract Aims Growth differentiation factor 15 (GDF15) has emerged as a promising metabolic regulator with hepatoprotective properties in metabolic dysfunction‐associated steatotic liver disease (MASLD), yet its underlying mechanisms remain elusive.
Jia Li, Qi Zhou, Mengmeng Xia, Yakun Li, Junyu Wang, Manon Buist‐Homan, Vincent E. de Meijer, Hans Blokzijl, Klaas Nico Faber, Han Moshage   +9 more
wiley   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Ion Transport Across a Bilayer Lipid Membrane in the Presence of Dilute Tetraphenylborate

Electroanalysis, Volume 38, Issue 4, April 2026.
The relationship between the membrane potential and the steady‐state current was recorded by normal pulse voltammetry. It is proved that the relationship symmetrical about the origin point (0 V, 0 A) mainly results from not only the transport of TPhB− but also that of Na+ between W1 and W2 across the BLM.
Yusuke Yamada, Keisei Sowa, Yuki Kitazumi, Osamu Shirai   +3 more
wiley   +1 more source