Results 41 to 50 of about 1,518 (175)

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Quantitative Structure-Permeation Relationships for Solute Transport Across Silicone Membranes [PDF]

, 2018
Purpose. The purpose of this work was to assess the molecular properties that influence solute permeation across silicone membranes and to compare the results with transport across human skin. Methods.
Boss, Gilles, Bunge, Annette, Carrupt, Pierre-Alain, Geinoz, Sandrine, Guy, Richard, Reist, Marianne, Rey, Sebastien, Testa, Bernard   +7 more
core  

2,4-Dinitrophenol, the inferno drug: a netnographic study of user experiences in the quest for leanness. [PDF]

, 2016
Background: Despite not being licensed for human consumption, the Internet has triggered renewed, widespread interest and availability of 2,4-Dinitrophenol (DNP).
BBC, Cann H. M., Cullen P., Duchaine D., Evans-Brown M., Gillham B., Hamilton A., Hecht A., Jennifer Germain, Jim McVeigh, Kurt T. L., Le P., Llewellyn W., Marie Claire Van Hout, Matharu H., McFee R. B., Morris S, Reuter P., Rheingold H., Saba V. K., Sawer P., Wallendorf M., Wise J.   +22 more
core   +1 more source

Applications of Lysosome‐Targeting Receptors (LTRs) in Targeted Protein Degradation

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Targeted protein degradation based on LYTAC technology has recently emerged as a research hotspot in various diseases. The membrane receptors recently utilized in LYTAC design are summarized in this article, with insights into current strategies, challenges, and prospects for LYTAC‐based technologies.
Lijian Shen, Ziyi Liang, Ying Zhang, Jing Wen, Jie Gao   +4 more
wiley   +1 more source

In search of an optimal acid-base indicator for examining surfactant micelles:Spectrophotometric studies and molecular dynamics simulations [PDF]

, 2019
We report on combined experimental and theoretical investigations of the water/micelle interface of cationic, anionic, zwitterionic, and non-ionic surfactants using a new hydrophobic acid-base indicator 2,6-dinitro-4-n-dodecylphenol.
Cheipesh, Tatyana A., Farafonov, Vladimir S., Lebed, Alexander V., Mchedlov-Petrossyan, Nikolay O., Nerukh, Dmitry A., Shekhovtsov, Sergey V.   +5 more
core   +1 more source

Antibody Polyreactivity: A Challenger of Immune Paradigms

Immunology, Volume 176, Issue 4, Page 421-437, December 2025.
This review article discusses the definition and functions of polyreactive antibodies, as well as their physiological roles. It also presents the concept of polyreactivity as a challenger of immunological dogmas. ABSTRACT Polyreactivity refers to the ability of antibodies to bind multiple unrelated antigens, encompassing polyspecificity and promiscuity.
Anastas D. Pashov, Jordan D. Dimitrov
wiley   +1 more source

Automated Analysis of Pollutants in Wastewater Using Atmospheric Pressure Gas Chromatography‐Tandem Quadrupole Mass Spectrometer With Robotic Autosampler and Solid Phase Micro Extraction

Journal of Separation Science, Volume 48, Issue 11, November 2025.
ABSTRACT The analysis of organic pollutants using gas chromatography coupled to mass spectrometer (GC‐MS) with electron impact (EI) ionization and liquid–liquid or solid‐phase extraction (LLE or SPE) often suffer from a limited selectivity and arduous sample preparation.
Dnyaneshwar Shinde, Urvikkumar Dhagat, Vijayakumar Murugan, Parth Gupta, Raghu Tadala, Bhaskar Karubothula, Chaitanya Devireddy, Edward Stanislaus, Samara Bin Salem, Wael Elamin, Grzegorz Brudecki   +10 more
wiley   +1 more source

Infrared spectroscopic studies of hydrogen bonding in substituted nitrophenols: substituent and solvent effects [PDF]

, 1992
A detailed infrared spectroscopic study of the substituted phenols 2-cyano-4,6-dinitrophenol and 4-cyano-2,6-dinitrophenol has been carried out (in several different solvents) in order to investigate the substituent and solvent effects on their intra ...
Castilho, Paula C. M. F., Crampton, Michael R., Yarwood, Jack   +2 more
core   +1 more source

Time Constraints Modulate the Effects of Predator Cues and a Metal Across Life Stages in a Damselfly

Evolutionary Applications, Volume 18, Issue 11, November 2025.
ABSTRACT Animals are increasingly exposed to multiple co‐occurring stressors. Environmental factors such as seasonal time constraints (TC), predation risk, and pollutants strongly influence fitness‐related traits in aquatic organisms. Yet, the interactive effects of such stressors, especially across life stages, remain unclear.
Nermeen R. Amer, Maria J. Golab, Robby Stoks, Guillaume Wos, Szymon Sniegula   +4 more
wiley   +1 more source