Results 111 to 120 of about 136,601 (306)

A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety

Advanced Science, EarlyView.
Schematic diagram showing the Cbln2+ ICx–dPAG circuit for sound‐driven defensive and anxiety‐like behaviors. ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined.
Jie Cao, Xingxing Lai, Lifang Huo, Zhouyuan Zheng, Qian Zhang, Zhimin Ye, Panpan Wan, Chao Ma, Congping Shang   +8 more
wiley   +1 more source

L’Unità di Dio in Descartes

Educação e Filosofia, 2015
[1] *Sigle: B = René Descartes . Tutte le lettere 1619 - 1650 (2005), a cura di G. Belgioioso, con la collaborazione di I. Agostini, F. Marrone, F. A. Meschini, M. Savini e di J. - R. Armogathe, Bompiani, Milano, 2009; B Op I = René Descartes. Opere 1637 - 1649, a cura di G. Belgioioso, con la collaborazione di I. Agostini, F. Marrone, M.
openaire   +4 more sources

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Light‐Driven Control of Polar Order in Ferroelectric Nematic Liquid Crystals

Angewandte Chemie, EarlyView.
Light‐responsive ferroelectric nematics are achieved by molecularly matching azobenzene photo‐switches to the polar packing motif of DIO. This design yields intrinsically photo‐responsive ferroelectric nematic mesogens and optically addressable DIO blends, in which light reversibly modulates spontaneous polarization and switches between high‐ and low ...
Anjali Devi Das, Xiuhu Zhao, Dibyojeet Bagchi, Kennice Brennan, Danqing Liu, Ghislaine Vantomme   +5 more
wiley   +2 more sources

Phosphor‐Sensitized Ternary Organic Solar Cells Achieving 18.6% PCE via Ir(III)‐Mediated Triplet Energy Transfer and Non‐Radiative Recombination Suppression

Advanced Science, EarlyView.
A synergistic phosphor‐sensitization strategy (PSS) significantly enhances ternary OSCs performance. By integrating an Ir‐3 complex as a triplet energy mediator within a pyrazine‐based (N2) ternary blend (PM6:N2: L8‐BO) doped with 1 wt.% of Ir‐3 complex, and a PCE of 18.6% is achieved through efficient triplet‐triplet energy transfer (TTET), suppressed
Priyanka Yadav, Guohong Liu, Hyerin Kim, Songhyun Kim, Minsung Kim, Yeongbin Ma, Jisan Lim, Young Yong Kim, Taehyung Jang, Raja Kumaresan, Jinhwan Yoon, Sung‐Ho Jin   +11 more
wiley   +1 more source

Mirror versus Inversion Symmetry Breaking in Mesogenic Dimers: NTB versus NF Phase

Angewandte Chemie, EarlyView.
Two non‐conventional nematic phases, twist‐bend NTB and ferroelectric NF, are observed within the same homologous series of dimers built of two strongly dipolar mesogenic units linked by a flexible spacer. The type of the phase formed depends on the molecular geometry, defined by parity of internal linkage.
Małgorzata Bakiera, Jakub Karcz, Damian Pociecha, Katarzyna Kwiatkowska, Mateusz Pawlak, Przemysław Kula, Ewa Gorecka   +6 more
wiley   +2 more sources

Carta de Juan de Dios Torres para Fernando Caicedo Flórez

4 ImágenesCarta de Juan de Dios Torres para Fernando Caicedo Flórez felicitándolo por su regreso a la patria.
Torres, Juan de Dios
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