Results 121 to 130 of about 136,601 (306)

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

open access: yesAdvanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen   +13 more
wiley   +1 more source

Intratumoral Fusogenic Outer Membrane Vesicles Enhance Antitumor Immunity Through Tumor MHC‐I Upregulation and Tumor Bacterization

open access: yesAdvanced Science, EarlyView.
Tumor bacterization by fusogenic outer membrane vesicles enhances microbial‐like recognition of tumor cells while activating the TLR4–NF‐κB–NLRC5 axis to upregulate MHC class I expression. By simultaneously strengthening APC sensing and T‐cell recognition, this strategy breaks tumor immune invisibility and promotes more effective antitumor immune ...
Xing Liu   +9 more
wiley   +1 more source

La conclusión anticipada en el delito de omisión a la asistencia familiar en el distrito judicial de Madre de Dios - Tambopata - 2016 [PDF]

open access: yes, 2018
La presente investigación parte del problema: ¿La conclusión anticipada influye en la resolución eficaz del proceso por el delito de omisión a la asistencia familiar en el Distrito Judicial de Madre de Dios-Tambopata-2016?, siendo como Objetivo ...
Ccahuantico Mesa, Leandro   +1 more
core   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

open access: yesAdvanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix   +16 more
wiley   +1 more source

La imagen del maestro presente en la película “Buscando a Forrester”

open access: yesPráxis Pedagógica, 2007
El artículo es un producto dela Investigaciónen curso que actualmente lleva a cabo el grupo de Investigación de semiótica dela Facultadde Educación de Uniminuto con título: “semiótica del cine”.
William l. Perdomo Vanegas   +3 more
doaj  

Free Charge Generation in Organic Photoconversion Devices–the Impact of Electrostatic Potentials

open access: yesAdvanced Energy Materials, EarlyView.
Free charge generation in organic photovoltaic and photodetector devices typically requires an external driving force to separate bound excitons formed upon photoexcitation. This review details how electrostatic potentials, arising from molecular charge distributions in organic semiconductors, can impact interfacial energetic landscapes and promote ...
Emily J. Yang   +3 more
wiley   +1 more source

La educación económica y financiera y su implicación en el Centro Regional Madrid

open access: yesPerspectivas, 2018
En la actualidad, el crecimiento de las pymes se ha convertido en un factor clave para el desarrollo regional por su alto impacto en la generación de empleo y producción.
Olga Vásquez   +3 more
doaj  

Evolutionary history and taxonomy of the genus Zea

open access: yesAmerican Journal of Botany, EarlyView.
Abstract Premise Taxonomic differentiation of teosinte species (Zea spp.), the closest relatives of maize (Z. mays) is crucial for understanding their distribution, ecology, and evolutionary history. Resolving the taxonomic uncertainties is of scientific interest and has practical implications for biodiversity management, preservation, and utilization.
José de Jesús Sánchez González   +4 more
wiley   +1 more source

A Novel Constitutional TUBB Variant Associated With Familial Malformations of Cortical Development

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Most pathogenic tubulin variants arise de novo in sporadic patients, causing severe brain malformations and significant neurodevelopmental impairment. The resulting reproductive disadvantage typically prevents these mutations from being transmitted to offspring.
Elena Cellini   +9 more
wiley   +1 more source

NOTI Minuto - agosto 2024

open access: yes
El boletín NOTI Minuto es una publicación digital de acceso abierto, publicado mensualmente en versión electrónica por la Organización El Minuto de ...
Organización El Minuto de Dios
core  

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