Results 21 to 30 of about 32,141 (242)

Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan

open access: yesEnvironmental Health and Preventive Medicine, 2019
Background Over the past few decades, the Japanese Ministry of the Environment has been biomonitoring dioxins in the general Japanese population and, in response to public concerns, has taken measures to reduce dioxin exposure.
Basilua Andre Muzembo   +6 more
doaj   +1 more source

Dioxin and Dioxin-like Compounds and Human Health

open access: yesToxics, 2023
In epidemiological studies, associations of dioxin and dioxin-like (dl)-compound exposure with metabolic diseases, including diabetes and metabolic syndrome, in adults and with neurodevelopmental problems and earlier/later puberty in children have been suggested in the general population and in environmentally exposed populations [...]
openaire   +3 more sources

Potential role of 2,2'-biphenylquinones in the carcinogenic/anti-cancer activity of dioxins [PDF]

open access: yes, 2008
Modes of carcinogenicity for the well-known environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been investigated over the past several decades. However, the mechanisms underlying TCDD carcinogenicity are still unclear.
Sierra Rayne
core   +1 more source

The Seveso accident: A look at 40 years of health research and beyond

open access: yesEnvironment International, 2018
A 1976 chemical factory explosion near Seveso, Italy exposed residents to high levels of 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD or dioxin). Dioxin is a known human carcinogen and potent endocrine disruptor. It is highly lipophilic and has a long half-
Brenda Eskenazi   +5 more
doaj   +1 more source

Novel Therapeutic Targets for the Treatment of Atopic Dermatitis

open access: yesBiomedicines, 2023
Atopic dermatitis (AD) is a chronic inflammatory skin disease that significantly impacts quality of life. The pathogenesis of AD is a complex combination of skin barrier dysfunction, type II immune response, and pruritus. Progress in the understanding of
Gaku Tsuji   +5 more
doaj   +1 more source

Mortality in New Zealand workers exposed to phenoxy herbicides and dioxins. [PDF]

open access: yes, 2004
AIMS: To evaluate mortality in New Zealand phenoxy herbicide producers and sprayers exposed to dioxins. METHODS: Phenoxy herbicide producers (n = 1025) and sprayers (n = 703) were followed up from 1 January 1969 and 1 January 1973 respectively to 31 ...
McLean, D   +12 more
core   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

open access: yesAdvanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han   +10 more
wiley   +1 more source

Lower chlorinated dioxins and dioxin-like compounds in samples from the paper industry

open access: yes, 2022
S.339-340A study concerning the occurrence of dioxin-like compounds in samples from the paper industry has been carried out. Some final extracts of selected samples (deinking sludge, paper mill biosludge, solid fiber board) were analysed for lower ...
Gruber, L., Santl, H.
core   +1 more source

Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.

open access: yesPLoS ONE, 2012
Environmental compounds can promote epigenetic transgenerational inheritance of adult-onset disease in subsequent generations following ancestral exposure during fetal gonadal sex determination.
Mohan Manikkam   +3 more
doaj   +1 more source

Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal dioxin exposure in Vietnam: a nested case-control study for neurobiomarker discovery. [PDF]

open access: yesPLoS ONE, 2015
In our previous study of 3-year-old children in a dioxin contamination hot spot in Vietnam, the high total dioxin toxic equivalent (TEQ-PCDDs/Fs)-exposed group during the perinatal period displayed lower Bayley III neurodevelopmental scores, whereas the ...
Muneko Nishijo   +10 more
doaj   +1 more source

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