Results 11 to 20 of about 1,130 (145)

NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion

Scientific Reports, 2017
Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) is a carcinogenic and highly toxic industrial byproduct that persists in the environment and produces a pleiotropic toxicity syndrome across vertebrate species that includes wasting, hepatosteatosis, and
Silvia Diani-Moore, Jenny Shoots, Rubi Singh, Joshua B. Zuk, Arleen B. Rifkind   +4 more
doaj   +1 more source

Mechanistic insight into the effects of Aryl Hydrocarbon Receptor activation on osteogenic differentiation

Bone Reports, 2017
While inhibition of bone healing and increased rates of pseudarthrosis are known adverse outcomes associated with cigarette smoking, the underlying mechanisms by which this occurs are not well understood.
Chawon Yun, Joseph A. Weiner, Danielle S. Chun, Jonghwa Yun, Ralph W. Cook, Michael S. Schallmo, Abhishek S. Kannan, Sean M. Mitchell, Ryan D. Freshman, Christian Park, Wellington K. Hsu, Erin L. Hsu   +11 more
doaj   +1 more source

Genetic Control of MAP3K1 in Eye Development and Sex Differentiation

Cells, 2021
The MAP3K1 is responsible for transmitting signals to activate specific MAP2K-MAPK cascades. Following the initial biochemical characterization, genetic mouse models have taken center stage to elucidate how MAP3K1 regulates biological functions.
Jingjing Wang, Eiki Kimura, Maureen Mongan, Ying Xia   +3 more
doaj   +1 more source

Effects of Dioxin on DNA Damage in the Testes of Adult Male Mice

Pharmaceutical and Biomedical Research, 2023
Background: Given the importance of environmental factors and the impact of environmental pollutants, such as dioxins, on organ systems, especially the reproductive system, it is necessary to study these issues and the mechanisms of their effects ...
Shabnam Mohammadi, Narjes Jalilvand, Fatemeh Esfandiari, Seyed Saleh Attari   +3 more
doaj  

Flavin-Containing Monooxygenase 3 (FMO3) Is Critical for Dioxin-Induced Reorganization of the Gut Microbiome and Host Insulin Sensitivity

Metabolites, 2022
Exposure to some environmental pollutants can have potent endocrine-disrupting effects, thereby promoting hormone imbalance and cardiometabolic diseases such as non-alcoholic fatty liver disease (NAFLD), diabetes, and cardiorenal diseases.
William Massey, Lucas J. Osborn, Rakhee Banerjee, Anthony Horak, Kevin K. Fung, Danny Orabi, E. Ricky Chan, Naseer Sangwan, Zeneng Wang, J. Mark Brown   +9 more
doaj   +1 more source

New strategy toward dioxin risk reduction for local residents surrounding severe dioxin hotspots in Vietnam

Global Health Action, 2013
Background: A public health intervention program with active involvement of local related stakeholders was piloted in the Bien Hoa dioxin hotspot (2007–2009), and then expanded to the Da Nang dioxin hotspot in Vietnam (2009–2011).
Vu-Anh Le, Ngoc-Bich Nguyen, Tuyet-Hanh Thi Tran   +2 more
doaj   +1 more source

Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities

BMC Genomics, 2010
Background The major toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) appear to result from dysregulation of mRNA levels mediated by the aryl hydrocarbon receptor (AHR). Dioxin-like chemicals alter expression of numerous genes in liver, but it
Okey Allan B, Chen Hanbo, Boutros Paul C, Moffat Ivy D, Pohjanvirta Raimo   +4 more
doaj   +1 more source

Tunable Oxygen Connectivity in Carbaporphyrinoid Polymers on Metal Surfaces

Angewandte Chemie, EarlyView.
Hydroxyl‐functionalized dicarbaporphyrinoid polymers synthesized on Au(111) enable tunable oxygen‐mediated connectivity under UHV conditions. Thermal activation yields one‐dimensional hydroxyl‐terminated polymers that can selectively evolve into either covalently‐linked dibenzo‐p‐dioxane architectures through intermolecular C–O–C coupling or two‐fold ...
Alberto Martínez‐Bajo, Maxence Urbani, Ana Barragán, Óscar Jover, Elena Pérez‐Elvira, Ilaria Tomei, Claudio Goletti, Alejandro Jiménez‐Martín, Aurelio Gallardo, Koen Lauwaet, David Écija, Diego Soler‐Polo, Marco Di Giovannantonio, Tomás Torres, José I. Urgel   +14 more
wiley   +2 more sources

Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan

Environmental Health and Preventive Medicine, 2019
Background Over the past few decades, the Japanese Ministry of the Environment has been biomonitoring dioxins in the general Japanese population and, in response to public concerns, has taken measures to reduce dioxin exposure.
Basilua Andre Muzembo, Miyuki Iwai-shimada, Tomohiko Isobe, Kokichi Arisawa, Masayuki Shima, Tetsuhito Fukushima, Shoji F. Nakayama   +6 more
doaj   +1 more source

Dioxin and Dioxin-like Compounds and Human Health

Toxics, 2023
In epidemiological studies, associations of dioxin and dioxin-like (dl)-compound exposure with metabolic diseases, including diabetes and metabolic syndrome, in adults and with neurodevelopmental problems and earlier/later puberty in children have been suggested in the general population and in environmentally exposed populations [...]
openaire   +3 more sources