Advanced Intelligent Discovery, EarlyView.Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova +4 more
wiley +1 more source
Oxygen Activation by Mononuclear Mn, Co, and Ni Centers in Biology and Synthetic Complexes [PDF]
, 2017 The active sites of metalloenzymes that catalyze O2-dependent reactions generally contain iron or copper ions. However, several enzymes are capable of activating O2 at manganese or nickel centers instead, and a handful of dioxygenases exhibit activity ...
Fiedler, Adam T., Fischer, Anne A.
core +1 more source
A foundation for provitamin A biofortification of maize: genome-wide association and genomic prediction models of carotenoid levels. [PDF]
, 2014 Efforts are underway for development of crops with improved levels of provitamin A carotenoids to help combat dietary vitamin A deficiency. As a global staple crop with considerable variation in kernel carotenoid composition, maize (Zea mays L.) could ...
Buckler, Edward S +13 more
core +1 more source
Genomic variations associated with attenuation in Mycobacterium avium subsp paratuberculosis vaccine strains [PDF]
, 2013 BACKGROUND: Mycobacterium avium subspecies paratuberculosis (MAP) whole cell vaccines have been widely used tools in the control of Johne's disease in animals despite being unable to provide complete protection. Current vaccine strains derive from stocks
Bull, TJ +7 more
core +1 more source
Production of maleylpyruvate and fumarylpyruvate
浙江大学学报. 农业与生命科学版, 2005 Gentisate 1,2-dioxygenase (GDO, EC1.14.13) from Klebsiella pneumoniae M5a1 successfully converted gentisate to maleylpyruvate. This biotransformation was performed by using genetically engineered E.
LIU Dong-qi, LIU Hong, ZHOU Ning-yi
doaj +1 more source
Substrate Oxidation by Indoleamine 2,3-Dioxygenase
Journal of Biological Chemistry, 2015 The kynurenine pathway is the major route of l-tryptophan (l-Trp) catabolism in biology, leading ultimately to the formation of NAD+. The initial and rate-limiting step of the kynurenine pathway involves oxidation of l-Trp to N-formylkynurenine.
E. Booth +4 more
semanticscholar +1 more source
Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-γ [PDF]
, 1989 Ernst R. Werner +5 more
openalex +1 more source
Journal of Biological Chemistry, 2013 Background: Tet methylcytosine dioxygenase converts 5-mC to 5-hmC in DNA. Results: Ascorbate significantly and specifically enhances Tet-mediated generation of 5-hmC.
E. Minor +3 more
semanticscholar +1 more source
Obesity and cancer: existing and new hypotheses for a causal connection [PDF]
, 2018 Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly, but recent evidence suggests a major role for chronic inflammation in cancer
Darlington, L. Gail +2 more
core +2 more sources
Tryptophan recycling is responsible for the interferon‐γ resistance of Chlamydia psittaci GPIC in indoleamine dioxygenase‐expressing host cells [PDF]
, 2004 Heidi Wood +2 more
openalex +1 more source