Results 11 to 20 of about 125,762 (338)

Hemoglobin: A Nitric-Oxide Dioxygenase [PDF]

open access: yesScientifica, 2012
Members of the hemoglobin superfamily efficiently catalyze nitric-oxide dioxygenation, and when paired with native electron donors, function as NO dioxygenases (NODs).
Paul R. Gardner
doaj   +4 more sources

High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome [PDF]

open access: yesHaematologica, 2008
Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine 2,3-dioxygenase can create immune suppression ...
Martine E.D. Chamuleau   +8 more
doaj   +7 more sources

Hydroperoxylation by Hydroxyethylphosphonate Dioxygenase [PDF]

open access: yesJournal of the American Chemical Society, 2009
Hydroxyethylphosphonate dioxygenase (HEPD) catalyzes the O(2)-dependent cleavage of the carbon-carbon bond of 2-hydroxyethylphosphonate (2-HEP) to afford hydroxymethylphosphonate (HMP) and formate without input of electrons or use of any organic cofactors. Two mechanisms have been proposed to account for this reaction.
Robert M. Cicchillo   +3 more
openaire   +3 more sources

The Contribution of Plant Dioxygenases to Hypoxia Signaling

open access: yesFrontiers in Plant Science, 2020
Dioxygenases catalyze the incorporation of one or two oxygen atoms into target organic substrates. Besides their metabolic role, these enzymes are involved in plant signaling pathways as this reaction is in several instances required for hormone ...
Sergio Iacopino   +5 more
doaj   +1 more source

Structure of an aromatic-ring-hydroxylating dioxygenase – naphthalene 1,2-dioxygenase [PDF]

open access: yesStructure, 1998
Pseudomonas sp. NCIB 9816-4 utilizes a multicomponent enzyme system to oxidize naphthalene to (+)-cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. The enzyme component catalyzing this reaction, naphthalene 1,2-dioxygenase (NDO), belongs to a family of aromatic-ring-hydroxylating dioxygenases that oxidize aromatic hydrocarbons and related compounds to cis ...
Björn Kauppi   +6 more
openaire   +3 more sources

Substrate stereo‐specificity in tryptophan dioxygenase and indoleamine 2,3‐dioxygenase [PDF]

open access: yesProteins: Structure, Function, and Bioinformatics, 2010
AbstractThe first and rate‐limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to N‐formylkynurenine is catalyzed by two heme‐containing proteins, Indoleamine 2,3‐dioxygenase (IDO), and Tryptophan 2,3‐dioxygenase (TDO). In mammals, TDO is found exclusively in liver tissue, IDO is found ubiquitously in all tissues.
Syun Ru Yeh   +5 more
openaire   +3 more sources

Alteration of the Substrate Specificity of the Angular Dioxygenase Carbazole 1,9a-Dioxygenase [PDF]

open access: yesBioscience, Biotechnology, and Biochemistry, 2008
Carbazole 1,9a-dioxygenase (CARDO) consists of terminal oxygenase (CARDO-O) and electron transport components. CARDO can catalyze specific oxygenation for various substrates: angular dioxygenation for carbazole and dibenzo-p-dioxin, lateral dioxygenation for anthracene, and monooxygenation for methylene carbon of fluorene and sulfide sulfur of ...
Hiroshi Habe   +15 more
openaire   +3 more sources

Discovery and Characterization of a Second Mammalian Thiol Dioxygenase, Cysteamine Dioxygenase [PDF]

open access: yesJournal of Biological Chemistry, 2007
There are only two known thiol dioxygenase activities in mammals, and they are ascribed to the enzymes cysteine dioxygenase (CDO) and cysteamine (2-aminoethanethiol) dioxygenase (ADO). Although many studies have been dedicated to CDO, resulting in the identification of its gene and even characterization of the tertiary structure of the protein ...
Chad R. Simmons   +5 more
openaire   +3 more sources

Changes in the Biotransformation of Green Tea Catechins Induced by Different Carbon and Nitrogen Sources in Aspergillus niger RAF106

open access: yesFrontiers in Microbiology, 2019
Biotransformation of green tea catechins mediated by microbes and/or enzymes could increase their bioavailability and improve their health benefits, but the regulatory mechanism remains unclear. Here, Aspergillus niger RAF106 isolated from Pu-erh tea was
Xiang Fang   +9 more
doaj   +1 more source

In silico recombinant plasmid design of pHA171 with phdABCD insertion for ethidium bromide degradation

open access: yesActa Biochimica Indonesiana, 2021
Background: Ethidium bromide is a common reagent that is used in nucleic acid staining. However, ethidium bromide has toxic and carcinogenic properties that are harmful to the environment.
Muhammad Ilham Fahri   +4 more
doaj   +1 more source

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